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Sonia Becharef
Researcher at Institut Gustave Roussy
Publications - 5
Citations - 3160
Sonia Becharef is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Immune system & Immunosurveillance. The author has an hindex of 4, co-authored 5 publications receiving 2151 citations. Previous affiliations of Sonia Becharef include French Institute of Health and Medical Research.
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Journal ArticleDOI
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Marie Vétizou,Marie Vétizou,Marie Vétizou,Jonathan M. Pitt,Jonathan M. Pitt,Jonathan M. Pitt,Romain Daillère,Romain Daillère,Romain Daillère,Patricia Lepage,Nadine Waldschmitt,Caroline Flament,Caroline Flament,Sylvie Rusakiewicz,Sylvie Rusakiewicz,Bertrand Routy,Maria Paula Roberti,Maria Paula Roberti,Connie P.M. Duong,Connie P.M. Duong,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Antoine Roux,Antoine Roux,Antoine Roux,Sonia Becharef,Sonia Becharef,Silvia C. Formenti,Encouse B. Golden,Sascha Cording,Gérard Eberl,Andreas Schlitzer,Florent Ginhoux,Sridhar Mani,Takahiro Yamazaki,Takahiro Yamazaki,Nicolas Jacquelot,Nicolas Jacquelot,Nicolas Jacquelot,David Enot,David Enot,Marion Bérard,Jérôme Nigou,Jérôme Nigou,Paule Opolon,Alexander M.M. Eggermont,Alexander M.M. Eggermont,Paul Louis Woerther,Elisabeth Chachaty,Nathalie Chaput,Nathalie Chaput,Caroline Robert,Caroline Robert,Christina Mateus,Guido Kroemer,Didier Raoult,Ivo G. Boneca,Ivo G. Boneca,Franck Carbonnel,Mathias Chamaillard,Laurence Zitvogel +60 more
TL;DR: A key role is revealed for Bacteroidales in the immunostimulatory effects of CTLA-4 blockade, which is found to depend on distinct Bacteroides species in mice and patients.
Journal ArticleDOI
Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects
Romain Daillère,Romain Daillère,Romain Daillère,Marie Vétizou,Marie Vétizou,Marie Vétizou,Nadine Waldschmitt,Takahiro Yamazaki,Takahiro Yamazaki,Christophe Isnard,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Connie P.M. Duong,Connie P.M. Duong,Caroline Flament,Caroline Flament,Patricia Lepage,Maria Paula Roberti,Maria Paula Roberti,Bertrand Routy,Bertrand Routy,Bertrand Routy,Nicolas Jacquelot,Nicolas Jacquelot,Nicolas Jacquelot,Lionel Apetoh,Lionel Apetoh,Sonia Becharef,Sonia Becharef,Sylvie Rusakiewicz,Sylvie Rusakiewicz,Philippe Langella,Harry Sokol,Harry Sokol,Guido Kroemer,David Enot,Antoine Roux,Alexander M. M. Eggermont,Alexander M. M. Eggermont,Eric Tartour,Ludger Johannes,Ludger Johannes,Ludger Johannes,Paul Louis Woerther,Elisabeth Chachaty,Jean-Charles Soria,Jean-Charles Soria,Encouse B. Golden,Silvia C. Formenti,Magdalena Plebanski,Mutsa Tatenda Madondo,Philip Rosenstiel,Didier Raoult,Vincent Cattoir,Ivo G. Boneca,Mathias Chamaillard,Laurence Zitvogel +57 more
TL;DR: Enterococcus hirae and B. intestinihominis represent valuable "oncomicrobiotics" ameliorating the efficacy of the most common alkylating immunomodulatory compound CTX, and selectively predicted longer progression-free survival in advanced lung and ovarian cancer patients treated with chemo-immunotherapy.
Journal ArticleDOI
Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade
Nicolas Jacquelot,Takahiro Yamazaki,Maria Paula Roberti,Connie P.M. Duong,Miles C. Andrews,Miles C. Andrews,Loic Verlingue,Loic Verlingue,Gladys Ferrere,Sonia Becharef,Marie Vétizou,Romain Daillère,Meriem Messaoudene,David Enot,Gautier Stoll,Stefano Ugel,Ilaria Marigo,Shin Foong Ngiow,Shin Foong Ngiow,Aurélien Marabelle,Aurélien Marabelle,Armelle Prévost-Blondel,Armelle Prévost-Blondel,Armelle Prévost-Blondel,Pierre Olivier Gaudreau,Vancheswaran Gopalakrishnan,Alexander M.M. Eggermont,Paule Opolon,Christophe Klein,Gabriele Madonna,Paolo A. Ascierto,Antje Sucker,Dirk Schadendorf,Mark J. Smyth,Mark J. Smyth,Jean-Charles Soria,Guido Kroemer,Vincenzo Bronte,Jennifer A. Wargo,Laurence Zitvogel +39 more
TL;DR: The deleterious role of signaling via the type I interferon (IFN) receptor in tumor and antigen presenting cells, that induced the expression of nitric oxide synthase 2 (NOS2), associated with intratumor accumulation of regulatory T cells and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody (mAb), is identified.
Journal ArticleDOI
Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer
Maria Paula Roberti,Maria Paula Roberti,Satoru Yonekura,Satoru Yonekura,Satoru Yonekura,Connie P.M. Duong,Connie P.M. Duong,Marion Picard,Marion Picard,Marion Picard,Gladys Ferrere,Gladys Ferrere,Maryam Tidjani Alou,Maryam Tidjani Alou,Conrad Rauber,Conrad Rauber,Conrad Rauber,Valerio Iebba,Valerio Iebba,Christian H. K. Lehmann,Lukas Amon,Diana Dudziak,Lisa Derosa,Lisa Derosa,Bertrand Routy,Bertrand Routy,Bertrand Routy,Caroline Flament,Caroline Flament,Corentin Richard,Romain Daillère,Romain Daillère,Aurélie Fluckiger,Aurélie Fluckiger,Isabelle Van Seuningen,Mathias Chamaillard,Audrey Vincent,Stephanie Kourula,Paule Opolon,Pierre Ly,Pierre Ly,Eugenie Pizzato,Eugenie Pizzato,Sonia Becharef,Sonia Becharef,Juliette Paillet,Juliette Paillet,Juliette Paillet,Christophe Klein,Florence Marliot,Filippo Pietrantonio,Stéphane Benoist,Jean-Yves Scoazec,Peggy Dartigues,Antoine Hollebecque,David Malka,Franck Pagès,Jérôme Galon,Ivo G. Boneca,Ivo G. Boneca,Patricia Lepage,Bernard Ryffel,Didier Raoult,Alexander M.M. Eggermont,Alexander M.M. Eggermont,Tom Vanden Berghe,François Ghiringhelli,Peter Vandenabeele,Guido Kroemer,Laurence Zitvogel +69 more
TL;DR: It is demonstrated that immunogenic ileal apoptosis contributes to the prognosis of chemotherapy-treated CC, and local microbiome composition influences treatment efficacy of chemotherapy in colon cancer via modulation of tolerogenic versus immunogenic IECs and the accumulation of T FH cells in patients with CC and mice.
Journal ArticleDOI
Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients.
Marion Picard,Satoru Yonekura,Satoru Yonekura,Satoru Yonekura,Karolina Slowicka,Ioanna Petta,Conrad Rauber,Conrad Rauber,Conrad Rauber,Bertrand Routy,Bertrand Routy,Bertrand Routy,Corentin Richard,Valerio Iebba,Maryam Tidjani Alou,Maryam Tidjani Alou,Sonia Becharef,Sonia Becharef,Pierre Ly,Pierre Ly,Eugenie Pizzato,Eugenie Pizzato,Christian H. K. Lehmann,Lukas Amon,Christophe Klein,Paule Opolon,Ivo G. Boneca,Ivo G. Boneca,Ivo G. Boneca,Jean-Yves Scoazec,Antoine Hollebecque,David Malka,François Ghiringhelli,Diana Dudziak,Geert Berx,Lars Vereecke,Geert van Loo,Guido Kroemer,Laurence Zitvogel,Maria Paula Roberti +39 more
TL;DR: It is suggested that chemotherapy inversely shapes the immune profile of the ileum–tumor axis, influencing clinical outcome.