S
Sonia Lozano
Researcher at GlaxoSmithKline
Publications - 14
Citations - 790
Sonia Lozano is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Plasmodium falciparum & Gametocyte. The author has an hindex of 9, co-authored 14 publications receiving 688 citations. Previous affiliations of Sonia Lozano include University of Wisconsin–Superior.
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Journal ArticleDOI
Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.
Lluis Ballell,Robert H. Bates,Robert J. Young,Daniel Alvarez-Gomez,Emilio Alvarez-Ruiz,Vanessa Barroso,Delia Blanco,Benigno Crespo,Jaime Escribano,Ruben R. Gonzalez,Sonia Lozano,Sophie Huss,Angel Santos-Villarejo,Jose Julio Martin-Plaza,Alfonso Mendoza,María José Rebollo-López,Modesto Jesus Remuinan-Blanco,Jose Luis Lavandera,Esther Pérez-Herrán,Francisco Javier Gamo-Benito,Jose F. Garcia-Bustos,David Barros,Julia Castro,Nicholas Cammack +23 more
TL;DR: With the aim of fuelling open‐source, translational, early‐stage drug discovery activities, the results of the recently completed antimycobacterial phenotypic screening campaign against Mycobacterium bovis BCG with hit confirmation in M. tuberculosis H37Rv were made publicly accessible.
Journal ArticleDOI
Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence “transmission blocking”assay
Joël Lelièvre,Maria Jesus Almela,Sonia Lozano,Celia Miguel,Virginia Franco,Didier Leroy,Esperanza Herreros +6 more
TL;DR: An efficient method to produce and purify mature gametocytes in vitro and an assay to determine the activity of antimalarial drugs based on the intracellular ATP content of purified stage IV–Vgametocytes after 48 h of drug exposure in 96/384-well microplates are designed.
Book ChapterDOI
Evaluation of a Bacterial Bioluminescence Bioassay as a Method for Predicting Acute Toxicity of Organic Chemicals to Fish
TL;DR: The relationship between the toxicity of 68 organic chemicals to fish and luminescent bacteria was evaluated in this article, where the feasibility of using the bacterial bioassay as a screening test in a cost-effective testing scheme was discussed.
Journal ArticleDOI
A New Set of Chemical Starting Points with Plasmodium falciparum Transmission-Blocking Potential for Antimalarial Drug Discovery.
Maria Jesus Almela,Sonia Lozano,Joël Lelièvre,Gonzalo Colmenarejo,Jose M. Coteron,Janneth Rodrigues,Carolina González,Esperanza Herreros +7 more
TL;DR: Screening results for the Tres Cantos Antimalarial Set (TCAMS) report the identification of 98 selective molecules with dual activity against gametocytes and asexual stages, and new chemical structures not connected to previously described antimalarials have been identified.
Journal ArticleDOI
Antifungal Activities and Cytotoxicity Studies of Six New Azasordarins
Esperanza Herreros,Maria Jesus Almela,Sonia Lozano,Federico Gómez de las Heras,Domingo Gargallo-Viola +4 more
TL;DR: In vitro selectivity of azasordarins showed significant activity against emerging fungal pathogens, which affect immunocompromised patients, such as Rhizopus arrhizus, Blastoschizomyces capitatus, and Geotrichum clavatum.