S
Sonia Schoonbroodt
Researcher at Morpho
Publications - 3
Citations - 699
Sonia Schoonbroodt is an academic researcher from Morpho. The author has contributed to research in topics: Matrix metalloproteinase & Somatic hypermutation. The author has an hindex of 3, co-authored 3 publications receiving 651 citations.
Papers
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Journal ArticleDOI
Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity
Rene Hoet,Edward H. Cohen,Rachel Baribault Kent,Kristin L. Rookey,Sonia Schoonbroodt,Shannon Hogan,Louise Rem,Nicolas Frans,Marc Daukandt,Henk Pieters,Rob van Hegelsom,Nicole Coolen-van Neer,Nastri Horacio G,Isaac J. Rondon,Jennifer A. Leeds,Simon E. Hufton,Lili Huang,Irina Kashin,Mary Devlin,Guannan Kuang,Mieke Steukers,Malini Viswanathan,Andrew E. Nixon,Daniel J. Sexton,Hennie R. Hoogenboom,Robert Charles Ladner +25 more
TL;DR: The construction of human Fab libraries having a unique combination of immunoglobulin sequences captured from human donors and synthetic diversity in key antigen contact sites in heavy-chain complementarity-determining regions 1 and 2 are reported.
Journal ArticleDOI
Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis.
Laetitia Devy,Lili Huang,Laurent Naa,Niranjan Yanamandra,Henk Pieters,Nicolas Frans,Edward F. Chang,Qingfeng Tao,Marc Vanhove,Annabelle Lejeune,Reinoud van Gool,Daniel J. Sexton,Guannan Kuang,Douglas Rank,Shannon Hogan,Csaba Pazmany,Yu Lu Ma,Sonia Schoonbroodt,Andrew E. Nixon,Robert Charles Ladner,Rene Hoet,Paula Henderikx,Chris TenHoor,Shafaat A. Rabbani,Maria-Luisa Valentino,Clive R. Wood,Daniel T. Dransfield +26 more
TL;DR: In this paper, the authors used a highly selective fully human MMP-14 inhibitory antibody discovered using phage display technology, which blocked proMMP-2 processing on tumor and endothelial cells, inhibited angiogenesis, and slowed tumor progression and formation of metastatic lesions.
Patent
Libraries and methods for isolating antibodies
TL;DR: In this paper, the disclosure features for identifying antibodies that bind to a carbohydrate moiety are provided, and the libraries can be provided by modifying a pre-existing nucleic acid library.