S
Sonia Waiczies
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 80
Citations - 2312
Sonia Waiczies is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Magnetic resonance imaging & T cell. The author has an hindex of 27, co-authored 77 publications receiving 2021 citations. Previous affiliations of Sonia Waiczies include Charité & University of Malta.
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Journal ArticleDOI
Treatment of Relapsing Paralysis in Experimental Encephalomyelitis by Targeting Th1 Cells through Atorvastatin
Orhan Aktas,Sonia Waiczies,Alina Smorodchenko,Jan Dörr,Bibiane Seeger,Timour Prozorovski,Stephanie Sallach,Matthias Endres,Stefan Brocke,Robert Nitsch,Frauke Zipp +10 more
TL;DR: It is demonstrated that both subcutaneous and oral administration of atorvastatin inhibit the development of actively induced chronic experimental autoimmune encephalomyelitis in SJL/J mice and significantly reduce the inflammatory infiltration into the central nervous system (CNS).
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Death Ligand TRAIL Induces No Apoptosis but Inhibits Activation of Human (Auto)antigen-Specific T Cells
Jan D. Lünemann,Sonia Waiczies,Stefan Ehrlich,Uwe Wendling,Bibiane Seeger,Thomas Kamradt,Frauke Zipp +6 more
TL;DR: Although it does not contribute to mechanisms of peripheral T cell tolerance such as clonal anergy or deletion by apoptosis, TRAIL can directly inhibit activation of human T cells via blockade of calcium influx.
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Oral High-Dose Atorvastatin Treatment in Relapsing-Remitting Multiple Sclerosis
Friedemann Paul,Sonia Waiczies,Jens Wuerfel,Judith Bellmann-Strobl,Jan Dörr,Helmar Waiczies,Mareile Haertle,Klaus D. Wernecke,Hans-Dieter Volk,Orhan Aktas,Frauke Zipp +10 more
TL;DR: MRI analysis indicates a possible beneficial effect of atorvastatin, alone or in combination with IFN-β, on the development of new gadolinium-enhancing lesion (CEL) in relapsing-remitting MS, and provides a rationale for phase II/III trials.
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Lack of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand But Presence of Its Receptors in the Human Brain
Jan Dörr,Ingo Bechmann,Sonia Waiczies,Orhan Aktas,Henning Walczak,Peter H. Krammer,Robert Nitsch,Frauke Zipp +7 more
TL;DR: The brain differs from other immune-privileged organs, such as the placenta, with the TRAIL receptor-TRAIL system not being part of the immune privilege of the brain.
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Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion
Katyayni Vinnakota,Feng Hu,Min-Chi Ku,Petya B. Georgieva,Frank Szulzewsky,Andreas Pohlmann,Sonia Waiczies,Helmar Waiczies,Thoralf Niendorf,Seija Lehnardt,Uwe-Karsten Hanisch,Michael Synowitz,Darko Markovic,Susanne A. Wolf,Rainer Glass,Helmut Kettenmann +15 more
TL;DR: Activation of TLR2 along with TLRs 1 and/or 6 converts microglia into a glioma supportive phenotype, and evidence is found that TLR1 and TLR6 cofunction withTLR2 as heterodimers in regulating MT1-MMP expression in vitro.