Sophie Donnet

Bio: Sophie Donnet is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Posterior probability & Prior probability. The author has an hindex of 18, co-authored 51 publications receiving 977 citations. Previous affiliations of Sophie Donnet include CEREMADE & Institut national de la recherche agronomique.

Combining Expert Opinions in Prior Elicitation

Abstract: We consider the problem of combining opinions from different experts in an explicitly model-based way to construct a valid subjective prior in a Bayesian statistical approach. We propose a generic approach by considering a hierarchical model accounting for various sources of variation as well as accounting for potential dependence between experts. We apply this approach to two problems. The first problem deals with a food risk assessment problem involving modelling dose-response for Listeria monocytogenes contamination of mice. Two hierarchical levels of variation are considered (between and within experts) with a complex mathematical situation due to the use of an indirect probit regression. The second concerns the time taken by PhD students to submit their thesis in a particular school. It illustrates a complex situation where three hierarchical levels of variation are modelled but with a simpler underlying probability distribution (log-Normal).

Combining expert opinions in prior elicitation

Abstract: A method of eliciting prior distributions for Bayesian models using expert knowledge is proposed. Elicitation is a widely studied problem, from a psychological perspective as well as from a statistical perspective. Here, we are interested in combining opinions from more than one expert using an explicitly model-based approach so that we may account for various sources of variation affecting elicited expert opinions. We use a hierarchical model to achieve this. We apply this approach to two problems. The first problem involves a food risk assessment problem involving modelling dose-response for Listeria monocytogenes contamination of mice. The second concerns the time taken by PhD students to submit their thesis in a particular school.

A review on estimation of stochastic differential equations for pharmacokinetic/pharmacodynamic models

Abstract: This paper is a survey of existing estimation methods for pharmacokinetic/pharmacodynamic (PK/PD) models based on stochastic differential equations (SDEs). Most parametric estimation methods proposed for SDEs require high frequency data and are often poorly suited for PK/PD data which are usually sparse. Moreover, PK/PD experiments generally include not a single individual but a group of subjects, leading to a population estimation approach. This review concentrates on estimation methods which have been applied to PK/PD data, for SDEs observed with and without measurement noise, with a standard or a population approach. Besides, the adopted methodologies highly differ depending on the existence or not of an explicit transition density of the SDE solution.

Stochastic block models for multiplex networks: an application to a multilevel network of researchers

Abstract: Modelling relationships between individuals is a classical question in social sci- ences and clustering individuals according to the observed patterns of interactions allows us to uncover a latent structure in the data. The stochastic block model is a popular approach for grouping individuals with respect to their social comportment. When several relationships of various types can occur jointly between individuals, the data are represented by multiplex networks where more than one edge can exist between the nodes. We extend stochastic block models to multiplex networks to obtain a clustering based on more than one kind of relation- ship. We propose to estimate the parameters—such as the marginal probabilities of assignment to groups (blocks) and the matrix of probabilities of connections between groups—through a variational expectation–maximization procedure. Consistency of the estimates is studied. The number of groups is chosen by using the integrated completed likelihood criterion, which is a penalized likelihood criterion. Multiplex stochastic block models arise in many situations but our applied example is motivated by a network of French cancer researchers. The two possi- ble links (edges) between researchers are a direct connection or a connection through their laboratories. Our results show strong interactions between these two kinds of connection and the groups that are obtained are discussed to emphasize the common features of researchers grouped together.

Invisible colleges : diffusion of knowledge in scientific communities

Abstract: No wonder you activities are, reading will be always needed. It is not only to fulfil the duties that you need to finish in deadline time. Reading will encourage your mind and thoughts. Of course, reading will greatly develop your experiences about everything. Reading invisible colleges diffusion of knowledge in scientific communities is also a way as one of the collective books that gives many advantages. The advantages are not only for you, but for the other peoples with those meaningful benefits.

An Introduction To The Theory Of Point Processes

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Penalising model component complexity: A principled, practical approach to constructing priors

Abstract: In this paper, we introduce a new concept for constructing prior distributions. We exploit the natural nested structure inherent to many model components, which defines the model component to be a flexible extension of a base model. Proper priors are defined to penalise the complexity induced by deviating from the simpler base model and are formulated after the input of a user-defined scaling parameter for that model component, both in the univariate and the multivariate case. These priors are invariant to reparameterisations, have a natural connection to Jeffreys' priors, are designed to support Occam's razor and seem to have excellent robustness properties, all which are highly desirable and allow us to use this approach to define default prior distributions. Through examples and theoretical results, we demonstrate the appropriateness of this approach and how it can be applied in various situations.

A First Course in the Numerical Analysis of Differential Equations: Stiff equations

Abstract: Cambridge University Press. Paperback. Book Condition: New. Paperback. 480 pages. Numerical analysis presents different faces to the world. For mathematicians it is a bona fide mathematical theory with an applicable flavour. For scientists and engineers it is a practical, applied subject, part of the standard repertoire of modelling techniques. For computer scientists it is a theory on the interplay of computer architecture and algorithms for real-number calculations. The tension between these standpoints is the driving force of this book, which presents a rigorous account of the fundamentals of numerical analysis of both ordinary and partial differential equations. The exposition maintains a balance between theoretical, algorithmic and applied aspects. This new edition has been extensively updated, and includes new chapters on emerging subject areas: geometric numerical integration, spectral methods and conjugate gradients. Other topics covered include multistep and Runge-Kutta methods; finite difference and finite elements techniques for the Poisson equation; and a variety of algorithms to solve large, sparse algebraic systems. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback.