Sophie Erhardt

TL;DR: A mechanism by which skeletal muscle PGC-1α1 induced by exercise training changes kynurenine metabolism and protects from stress-induced depression is described, opening therapeutic avenues for the treatment of depression by targeting the P GC-1β-PPAR axis in skeletal muscle, without the need to cross the blood-brain barrier.

TL;DR: A role is proposed for CSF IL-6 in the symptomatology of suicidal behavior, possibly through mechanisms involving alterations of dopamine and serotonin metabolism, and patients with increased blood-brain barrier permeability did not exhibit elevated cytokine levels.

TL;DR: CSF levels of kynurenic acid in schizophrenic patients were found to correlate with age, which is indicative of a contribution of kysine-site of the N-methyl D-aspartate-receptor in the pathogenesis of schizophrenia.

TL;DR: Clinical evidence of increased QUIN in the CSF of suicide attempters is presented and the correlation between QUIN and the Suicide Intent Scale indicates that changes in glutamatergic neurotransmission could be specifically linked to suicidality.

TL;DR: The results demonstrate increased levels of CSF KYN and KYNA in patients with schizophrenia and further support the hypothesis that KYNA is involved in the pathophysiology of schizophrenia.