S
Sophie Gallina
Researcher at university of lille
Publications - 31
Citations - 3943
Sophie Gallina is an academic researcher from university of lille. The author has contributed to research in topics: Locus (genetics) & Population. The author has an hindex of 17, co-authored 29 publications receiving 3673 citations. Previous affiliations of Sophie Gallina include Pasteur Institute & Lille University of Science and Technology.
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Journal ArticleDOI
Variation in FTO contributes to childhood obesity and severe adult obesity
Christian Dina,David Meyre,Sophie Gallina,Emmanuelle Durand,Antje Körner,Peter Jacobson,Lena M. S. Carlsson,Wieland Kiess,Vincent Vatin,Cécile Lecoeur,Jérôme Delplanque,Emmanuel Vaillant,François Pattou,Juan Ruiz,Jacques Weill,Claire Levy-Marchal,Fritz F. Horber,Natascha Potoczna,Serge Hercberg,Catherine Le Stunff,Pierre Bougnères,Peter Kovacs,Michel Marre,Beverley Balkau,Beverley Balkau,Stéphane Cauchi,Jean-Claude Chèvre,Philippe Froguel,Philippe Froguel +28 more
TL;DR: It is concluded that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.
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Genomewide Search for Type 2 Diabetes–Susceptibility Genes in French Whites: Evidence for a Novel Susceptibility Locus for Early-Onset Diabetes on Chromosome 3q27-qter and Independent Replication of a Type 2–Diabetes Locus on Chromosome 1q21–q24
Nathalie Vionnet,El Habib Hani,Sophie Dupont,Sophie Gallina,Stephan Francke,Sébastien Dotte,Frédérique De Matos,Emmanuelle Durand,Frédéric Leprêtre,Cécile Lecoeur,Philippe Gallina,Lirije Zekiri,Christian Dina,Philippe Froguel +13 more
TL;DR: Evidence for a novel susceptibility locus for type 2 diabetes in French whites on chromosome 3q27-qter is shown and the previously reported diabetes-susceptibility locus on chromosome 1q21-q24 is confirmed.
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Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
David Meyre,Jérôme Delplanque,Jean-Claude Chèvre,Cécile Lecoeur,Stéphane Lobbens,Sophie Gallina,Emmanuelle Durand,Vincent Vatin,Franck Degraeve,Christine Proença,Stefan Gaget,Antje Körner,Peter Kovacs,Wieland Kiess,Jean Tichet,Michel Marre,Anna-Liisa Hartikainen,Fritz F. Horber,Natascha Potoczna,Serge Hercberg,Claire Levy-Marchal,Claire Levy-Marchal,François Pattou,Barbara Heude,Maithé Tauber,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Alexandra I. F. Blakemore,Alexandre Montpetit,Constantin Polychronakos,Jacques Weill,Lachlan J. M. Coin,Julian E. Asher,Paul Elliott,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Sophie Visvikis-Siest,Beverley Balkau,Robert Sladek,David J. Balding,Andrew Walley,Christian Dina,Philippe Froguel,Philippe Froguel +44 more
TL;DR: In addition to FTO and MC4R, genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls detected significant association of obesity with three new risk loci in NPC1, near MAF and near PTER.
Journal ArticleDOI
Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.
Stéphane Cauchi,David Meyre,Christian Dina,Hélène Choquet,Chantal Samson,Sophie Gallina,Beverley Balkau,Guillaume Charpentier,François Pattou,Volodymyr Stetsyuk,Raphael Scharfmann,Bart Staels,Gema Frühbeck,Philippe Froguel +13 more
TL;DR: Evidence is provided that TCF7L2 is a major determinant of type 2 diabetes risk in European populations and suggests that this transcription factor plays a key role in glucose homeostasis.
Journal ArticleDOI
Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome.
Amélie Bonnefond,Emmanuelle Durand,Olivier Sand,Franck De Graeve,Sophie Gallina,Kanetee Busiah,Stéphane Lobbens,Albane Simon,Christine Bellanné-Chantelot,Louis Letourneau,Raphael Scharfmann,Jérôme Delplanque,Robert Sladek,Michel Polak,Martine Vaxillaire,Philippe Froguel,Philippe Froguel +16 more
TL;DR: Compared to the current Sanger protocol, WES is a comprehensive, cost-efficient and rapid method to identify mutations in NDM patients, and is suggested as a near future tool of choice for further molecular diagnosis of NDM cases.