S
Søren B. Jensen
Researcher at Aarhus University
Publications - 23
Citations - 3703
Søren B. Jensen is an academic researcher from Aarhus University. The author has contributed to research in topics: Innate immune system & Pattern recognition receptor. The author has an hindex of 15, co-authored 20 publications receiving 3098 citations. Previous affiliations of Søren B. Jensen include University of Massachusetts Medical School & University of Tromsø.
Papers
More filters
Journal ArticleDOI
IFI16 is an innate immune sensor for intracellular DNA.
Leonie Unterholzner,Sinead E. Keating,Marcin Baran,Kristy A. Horan,Søren B. Jensen,Søren B. Jensen,Shrutie Sharma,Cherilyn M. Sirois,Tengchuan Jin,Eicke Latz,Eicke Latz,T. Sam Xiao,Katherine A. Fitzgerald,Søren R. Paludan,Andrew G. Bowie +14 more
TL;DR: IFI16 (p204) is the first PYHIN protein to their knowledge shown to be involved in IFN-β induction and forms a new family of innate DNA sensors the authors call 'AIM2-like receptors' (ALRs).
Journal ArticleDOI
IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
Martin R. Jakobsen,Rasmus O. Bak,Annika Andersen,Randi K. Berg,Randi K. Berg,Søren B. Jensen,Tengchuan Jin,Anders Laustsen,Kathrine Hansen,Lars Østergaard,Katherine A. Fitzgerald,T. Sam Xiao,Jacob Giehm Mikkelsen,Trine H. Mogensen,Søren R. Paludan +14 more
TL;DR: IFI16 is a sensor for DNA forms produced during the lentiviral replication cycle and regulates HIV-1 replication in macrophages, which contribute to early control of the virus.
Journal ArticleDOI
Attenuation of cGAS-STING Signaling Is Mediated by a p62/SQSTM1-dependent Autophagy Pathway Activated by TBK1
Thaneas Prabakaran,Chiranjeevi Bodda,Chiranjeevi Bodda,Christian Krapp,Bao-Cun Zhang,Maria H Christensen,Chenglong Sun,Line S. Reinert,Yujia Cai,Søren B. Jensen,Morten K Skouboe,Jens R. Nyengaard,Craig B. Thompson,Robert Jan Lebbink,Ganes C. Sen,Geert van Loo,Rikke Nielsen,Masaaki Komatsu,Lene N. Nejsum,Martin R. Jakobsen,Mads Gyrd-Hansen,Søren R. Paludan +21 more
TL;DR: It is reported that STING degradation following activation of the pathway occurs through autophagy and is mediated by p62/SQSTM1, which is phosphorylated by TBK1 to direct ubiquitinated STING to autophagosomes.
Journal ArticleDOI
Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway
Kathrine Hansen,Thaneas Prabakaran,Anders Laustsen,Sofie E. Jørgensen,Stine H Rahbæk,Søren B. Jensen,Rikke Nielsen,Jess H. Leber,Thomas Decker,Kristy A. Horan,Martin R. Jakobsen,Søren R. Paludan +11 more
TL;DR: In human macrophages, Listeria DNA rather than cyclic‐di‐AMP is stimulating the IFN response via a pathway dependent on the DNA sensors IFI16 and cGAS as well as the signalling adaptor molecule STING.
Journal ArticleDOI
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
Kasper L Jønsson,Anders Laustsen,Christian Krapp,Christian Krapp,Kristian Alsbjerg Skipper,Karthiga Thavachelvam,Dominik Hotter,Johanne H Egedal,Mads Kjolby,Mads Kjolby,Pejman Mohammadi,Thaneas Prabakaran,Lambert K. Sørensen,Chenglong Sun,Søren B. Jensen,Christian K. Holm,Robert Jan Lebbink,Mogens Johannsen,Mette Nyegaard,Jacob Giehm Mikkelsen,Frank Kirchhoff,Søren R. Paludan,Martin R. Jakobsen +22 more
TL;DR: The results suggest that IFI16 is essential for efficient sensing and signalling upon DNA challenge in macrophages to promote interferons and antiviral responses.