S
Søren T. Hoff
Researcher at Hvidovre Hospital
Publications - 6
Citations - 1569
Søren T. Hoff is an academic researcher from Hvidovre Hospital. The author has contributed to research in topics: Vaccination & Innate immune system. The author has an hindex of 5, co-authored 6 publications receiving 1470 citations.
Papers
More filters
Journal ArticleDOI
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major.
Patricia A. Darrah,Dipti T. Patel,Paula M De Luca,Ross W. B. Lindsay,Dylan F. Davey,Barbara J. Flynn,Søren T. Hoff,Peter Andersen,Steven G. Reed,Sheldon L. Morris,Mario Roederer,Robert A. Seder +11 more
TL;DR: The quality of a CD4+ T-cell cytokine response can be a crucial determinant in whether a vaccine is protective, and may provide a new and useful prospective immune correlate of protection for vaccines based on T-helper type 1 (TH1) cells.
Journal ArticleDOI
Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection.
Jaap T. van Dissel,Darius Soonawala,Simone A. Joosten,Corine Prins,Sandra M. Arend,Peter Bang,Pernille N. Tingskov,Karen Lingnau,Jan Nouta,Søren T. Hoff,Ida Rosenkrands,Ingrid Kromann,Tom H. M. Ottenhoff,T. Mark Doherty,Peter Andersen +14 more
TL;DR: Safety and IFN-γ responses in healthy BCG-vaccinated and prior or latently TB-infected individuals receiving a novel vaccine composed of the fusion protein Ag85B-ESAT-6 combined with the adjuvant IC31(®) persisted through 32 weeks of follow-up, indicating the induction of a persistent memory response in the vaccine recipients.
Journal ArticleDOI
Evaluation of Mycobacterium tuberculosis-Specific Antibody Responses in Populations with Different Levels of Exposure from Tanzania, Ethiopia, Brazil, and Denmark
Søren T. Hoff,Markos Abebe,Pernille Ravn,Nyagosya Range,Wabyahe L. M. Malenganisho,Denise S. Rodriques,Esper G. Kallas,Christian Søborg,T. Mark Doherty,Peter Andersen,Karin Weldingh +10 more
TL;DR: This study confirms the presence of ESAT-6 and CFP-10 antibodies in patients with TB, and demonstrates that significant antibody responses are not restricted to active TB disease but can reflect latent infection, particularly in areas with high levels of exposure to M. tuberculosis.
Journal ArticleDOI
Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial.
Klaus Reither,Lynn Katsoulis,Trevor Beattie,Nicolene Gardiner,Nicole Lenz,Khadija Said,Elirehema Mfinanga,Christian Pohl,Katherine Fielding,Hannah Jeffery,Benjamin M. Kagina,Elisabeth J. Hughes,Thomas J. Scriba,Willem A. Hanekom,Søren T. Hoff,Peter Bang,Ingrid Kromann,Claudia Daubenberger,Peter Andersen,Gavin J. Churchyard +19 more
TL;DR: H1/IC31 was well tolerated and safe in HIV-infected adults with a CD4+ Lymphocyte count greater than 350 cells/mm3 and induced a specific and durable Th1 immune response.
Journal ArticleDOI
Antiviral Innate Immune Activation in HIV-Infected Adults Negatively Affects H1/IC31-Induced Vaccine-Specific Memory CD4+ T Cells.
Nicole Lenz,Tobias Schindler,Tobias Schindler,Benjamin M. Kagina,Jitao David Zhang,Tedson Lukindo,Maxmillian Mpina,Maxmillian Mpina,Peter Bang,Ingrid Kromann,Søren T. Hoff,Peter Andersen,Klaus Reither,Klaus Reither,Gavin J. Churchyard,Gavin J. Churchyard,Ulrich Certa,Claudia Daubenberger +17 more
TL;DR: In HIV-infected volunteers, expression levels of genes involved in the antiviral innate immune response affected long-term maintenance of H1/IC31 vaccine-induced cellular immunity.