Author
Souad Sfar
Bio: Souad Sfar is an academic researcher from University of Monastir. The author has contributed to research in topics: Drug delivery & Bioavailability. The author has an hindex of 16, co-authored 37 publications receiving 1598 citations.
Papers
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TL;DR: An increasing number of recent studies have aimed at designing novel resveratrol formulations to overcome its poor solubility, limited stability, high metabolization and weak bioavailability, which is a barrier to the development of therapeutic applications.
509 citations
TL;DR: A general review on the background and development of liposomes with a focus on preparation methods including classic (thin film hydration, reverse-phase evaporation, ethanol injection…) and novel scalable techniques and an opinion on the usefulness ofliposomes in various applications ranging from unsubstantiated optimism to undeserved pessimism is given.
Abstract: Liposomes, spherical-shaped nanovesicles, were discovered in the 60ies by Bangham. Since that, they were extensively studied as potential drug carrier. Due to their composition variability and structural properties, liposomes are extremely versatile leading to a large number of applications including pharmaceutical, cosmetics and food industrial fields. This bibliographic paper offers a general review on the background and development of liposomes with a focus on preparation methods including classic (thin film hydration, reverse-phase evaporation, ethanol injection…) and novel scalable techniques. Furthermore, liposome characterization techniques including mean size, zetapotential, lamellarity, encapsulation efficiency, in vitro drug release, vesicles stability and lipid analysis synthesized from different published works are reported. The current deepening and widening of liposome interest in many scientific disciplines and their application in pharmaceutics, cosmetics and food industries as promising novel breakthroughs and products were also handled. Finally, an opinion on the usefulness of liposomes in various applications ranging from unsubstantiated optimism to undeserved pessimism is given. The obtained information allows establishing criteria for selecting liposomes as a drug carrier according to its advantages and limitations.
498 citations
TL;DR: Results confirmed the robustness of the hollow fiber module based technique, which is simple, fast and has a potential for continuous production of nanosized liposome suspensions at large scale.
131 citations
TL;DR: In this paper, the authors obtained poly-epsilon-caprolactone nanospheres and nanocapsules of griseofulvin by nanoprecipitation and characterized them.
127 citations
TL;DR: Oral citrulline could play a pivotal role in maintaining protein homeostasis and is a promising pharmaconutrient in nutritional support strategies for malnourished patients, especially in aging and sarcopenia.
121 citations
Cited by
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TL;DR: This review briefly analyze how the efficacy of liposomes depends on the nature of their components and their size, surface charge, and lipidic organization, and describes some strategies developed to overcome limitations of the “first-generation” liposome-based drugs on the market and in clinical trials.
Abstract: Since their discovery in the 1960s, liposomes have been studied in depth, and they continue to constitute a field of intense research. Liposomes are valued for their biological and technological advantages, and are considered to be the most successful drug-carrier system known to date. Notable progress has been made, and several biomedical applications of liposomes are either in clinical trials, are about to be put on the market, or have already been approved for public use. In this review, we briefly analyze how the efficacy of liposomes depends on the nature of their components and their size, surface charge, and lipidic organization. Moreover, we discuss the influence of the physicochemical properties of liposomes on their interaction with cells, half-life, ability to enter tissues, and final fate in vivo. Finally, we describe some strategies developed to overcome limitations of the "first-generation" liposomes, and liposome-based drugs on the market and in clinical trials.
1,507 citations
TL;DR: A comparative analysis is given of the size, zeta-potential, dispersion pH, shell thickness, encapsulation efficiency, active substance release, stability and in vivo and in vitro pharmacological performances, which allows establishing criteria for selecting a method for preparation of nanocapsules according to its advantages, limitations and behaviours as a drug carrier.
1,462 citations
TL;DR: In this paper, a review of the preparation of polymer nanoparticles and the crucial parameters involved in techniques designed to obtain the desired properties is presented, and the choice of method depends on a number of factors, such as particle size, particle size distribution, area of application, etc.
1,393 citations
TL;DR: Bhushan S. Pattni,† Vladimir V. Chupin,‡ and Vladimir P. Torchilin study the role of phosphorous in the biosynthesis of Membrane Proteins and found that phosphorous binds to polypeptide A in a manner similar to that of polymethine.
Abstract: Bhushan S. Pattni,† Vladimir V. Chupin,‡ and Vladimir P. Torchilin*,†,§,∥ †Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Massachusetts 02115, United States ‡Laboratory for Advanced Studies of Membrane Proteins, Moscow Institute of Physics and Technology, Dolgoprudny 141700, Russia Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
1,124 citations