S
Spyros A. Kalams
Researcher at Vanderbilt University Medical Center
Publications - 159
Citations - 14398
Spyros A. Kalams is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Cytotoxic T cell & Epitope. The author has an hindex of 54, co-authored 145 publications receiving 13788 citations. Previous affiliations of Spyros A. Kalams include Howard Hughes Medical Institute & Rockefeller University.
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Journal ArticleDOI
Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia
Eric S. Rosenberg,James M. Billingsley,Angela M. Caliendo,Steven L. Boswell,Paul E. Sax,Spyros A. Kalams,Bruce D. Walker +6 more
TL;DR: In individuals who control viremia in the absence of antiviral therapy, polyclonal, persistent, and vigorous HIV-1-specific CD4+ T cell proliferative responses were present, resulting in the elaboration of interferon-gamma and antiviral beta chemokines.
Journal ArticleDOI
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
Kathleen L. Collins,Benjamin K. Chen,Spyros A. Kalams,Spyros A. Kalams,Bruce D. Walker,Bruce D. Walker,David Baltimore,David Baltimore +7 more
TL;DR: It is found that CTLs inefficiently lysed primary cells infected with HIV-1 if the viral nef gene product was expressed and Nef protected infected cells by reducing the epitope density on their surface.
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The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses
Spyros A. Kalams,Bruce D. Walker +1 more
TL;DR: For many viral infections, resolution of illness is associated with long-term host control of viremia rather than viral eradication, which suggests that it is the immune system that is holding the virus together.
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Factors Associated with the Development of Cross-Reactive Neutralizing Antibodies during Human Immunodeficiency Virus Type 1 Infection
D. Noah Sather,Jakob Armann,Jakob Armann,Lance K. Ching,Lance K. Ching,Angeliki Mavrantoni,Angeliki Mavrantoni,George Sellhorn,Zachary Caldwell,Xuesong Yu,Blake Wood,Steve Self,Spyros A. Kalams,Leonidas Stamatatos,Leonidas Stamatatos +14 more
TL;DR: It is indicated that more than one pathway leads to the development of broad cross-reactive neutralizing antibodies during HIV infection and that the virus continuously escapes their action.
Journal ArticleDOI
Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection.
Spyros A. Kalams,Susan Buchbinder,Eric S. Rosenberg,James M. Billingsley,D. S. Colbert,Norman G. Jones,Amy K. Shea,Alicja Trocha,Bruce D. Walker +8 more
TL;DR: Analysis of functional human immunodeficiency virus type 1 (HIV-1)-specific memory CTL precursor frequencies and p24-specific proliferative responses in a cohort of infected untreated persons provides cellular immunologic parameters to guide therapeutic and prophylactic vaccine development.