S
Spyros E. Zographos
Researcher at The Cyprus Institute of Neurology and Genetics
Publications - 73
Citations - 2262
Spyros E. Zographos is an academic researcher from The Cyprus Institute of Neurology and Genetics. The author has contributed to research in topics: Glycogen phosphorylase & Ligand (biochemistry). The author has an hindex of 27, co-authored 66 publications receiving 2092 citations. Previous affiliations of Spyros E. Zographos include University of Oxford & China Pharmaceutical University.
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Journal ArticleDOI
Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure−Activity Relationships, and X-ray Crystallographic Studies†
Xiaoan Wen,Hongbin Sun,Jun Liu,Keguang Cheng,Pu Zhang,Liying Zhang,Jia Hao,Luyong Zhang,Peizhou Ni,Spyros E. Zographos,Demetres D. Leonidas,K.-M. Alexacou,Thanasis Gimisis,Joseph Hayes,Nikos G. Oikonomakos +14 more
TL;DR: Pentacyclic triterpenes represent a promising class of multiple-target antidiabetic agents that exert hypoglycemic effects, at least in part, through GP inhibition.
Journal ArticleDOI
New Inhibitors of Glycogen Phosphorylase as Potential Antidiabetic Agents
László Somsák,Katalin Czifrák,Marietta Tóth,Éva Bokor,Evangelia D. Chrysina,K.-M. Alexacou,Joseph Hayes,C. Tiraidis,E. Lazoura,Demetres D. Leonidas,Spyros E. Zographos,Nikos G. Oikonomakos +11 more
TL;DR: The synthesis, structure determination and computational studies of the most recent inhibitors of glycogen phosphorylase at the different binding sites are presented and analyzed and have the potential to facilitate structure-based drug design.
Journal ArticleDOI
Potent inhibition of glycogen phosphorylase by a spirohydantoin of glucopyranose : first pyranose analogues of hydantocidin
C. J. F. Bichard,E. P. Mitchell,Mark R. Wormald,Kimberly A. Watson,Louise N. Johnson,Spyros E. Zographos,Demetra D. Koutra,Nikos G. Oikonomakos,George W. J. Fleet +8 more
TL;DR: This work reports the first example of specific enzyme inhibition by a spirohydantoin at the anomeric position of a sugar in the presence of glycogen phosphorylase.
Journal ArticleDOI
Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site.
Nikos G. Oikonomakos,Joachim B. Schnier,Spyros E. Zographos,Vicky T. Skamnaki,Katerina E. Tsitsanou,Louise N. Johnson +5 more
TL;DR: Both flavopiridol and glucose promote the less active T-state through localization of the closed position of the 280s loop which blocks access to the catalytic site, thereby explaining their synergistic inhibition.
Journal ArticleDOI
Kinetics, in silico docking, molecular dynamics, and MM-GBSA binding studies on prototype indirubins, KT5720, and staurosporine as phosphorylase kinase ATP-binding site inhibitors: The role of water molecules examined
Joseph Hayes,Vicky T. Skamnaki,Georgios Archontis,Christos Lamprakis,Josephine Sarrou,Nicolas Bischler,Alexios-Leandros Skaltsounis,Spyros E. Zographos,Nikos G. Oikonomakos +8 more
TL;DR: The PhKγtrnc‐staurosporine complex has the greatest number of receptor‐ligand hydrogen bonds, while for the indirubin‐3′‐oxime and KT5720 complexes there is an important network of interchanging water molecules bridging inhibitor‐enzyme contacts.