scispace - formally typeset
Search or ask a question
Author

Sreenath Pappuru

Bio: Sreenath Pappuru is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Ring-opening polymerization & Drug delivery. The author has an hindex of 8, co-authored 16 publications receiving 270 citations. Previous affiliations of Sreenath Pappuru include Technion – Israel Institute of Technology.

Papers
More filters
Journal ArticleDOI
TL;DR: Results suggest that PLA/HPG/Cur nanofibers can be a potential wound patch dressing for acute and chronic wound applications.

136 citations

Journal ArticleDOI
TL;DR: In this paper, the metal-free Lewis pair catalysts for ring-opening alternating copolymerization (ROAP) reactions were designed to enhance both activity and selectivity.

53 citations

Journal ArticleDOI
TL;DR: The in vitro drug release kinetic study displayed the slow sustained drug release behavior with anomalous transport for both DOX and CUR in a defined physiological environment, and the anti-tumor efficacy of all NDFs was examined on several different cancer cell lines and maximum cytotoxicity was observed in MIA PaCa-2 cells with low inhibitory concentration values.

39 citations

Journal ArticleDOI
TL;DR: A series of Ti(IV), Zr(IV) and Hf( IV) benzotriazole phenoxide (BTP) complexes were synthesized and characterized by various spectroscopic techniques, elemental analysis and X-ray crystallography and were found to be active towards the ring-opening polymerization (ROP) of L-lactide (L-LA) and rac-lactic acid (rac-LA).
Abstract: A series of Ti(IV), Zr(IV) and Hf(IV) benzotriazole phenoxide (BTP) complexes were synthesized and characterized by various spectroscopic techniques, elemental analysis and X-ray crystallography. The monosubstituted Zr(IV) BTP complexes [(μ-L)Zr(O(i)Pr)3]2 1-3 [L = (C1)BTP-H (1), (TCl)BTP-H (2), (pent)BTP-H (3)] and tetrasubstituted Zr(IV), Hf(IV) complexes ZrL4 4-6 [L = (C1)BTP-H (4), (TCl)BTP-H (5), (pent)BTP-H (6)] and HfL4 7-9 [L = (C1)BTP-H (7), (TCl)BTP-H (8), (pent)BTP-H (9)] were prepared by the reaction of Zr(O(i)Pr)4·((i)PrOH) and Hf(O(t)Bu)4 in toluene with the respective ligands in different stoichiometric proportions. The reaction between BTP and TiCl4 and ZrCl4 and HfCl4 in a 2 : 1 stoichiometric reaction resulted in the formation of disubstituted group IV chloride complexes L2MCl2 10-12 [L = (C1)BTP-H, M = Ti, Zr and Hf]. The molecular structures of complexes 1, 4, 7, 10, 11, and 12 were determined by single-crystal X-ray studies. The X-ray structure of 1 reveals a dimeric Zr(IV) complex containing a Zr2O2 core bridged through the oxygen atoms of the phenoxide groups. Each Zr atom is distorted from an octahedral symmetry. These complexes were found to be active towards the ring-opening polymerization (ROP) of L-lactide (L-LA) and rac-lactide (rac-LA). Complex 1 produced highly heterotactic poly(lactic acid) (PLA) from rac-LA under melt conditions with narrow molecular weight distributions (MWDs) and well controlled number average molecular weights (M(n)). Additionally, epoxide polymerizations using rac-cyclohexene oxide (CHO), rac-propylene oxide (PO), and rac-styrene oxide (SO) were also carried out with these complexes. The yield and molecular weight of the polymer was found to increase with the extension of reaction time. Compounds 1-12 were activated by methylaluminoxane (MAO) and show good activity for ethylene polymerization and produced high molecular weight polyethylene.

39 citations

Journal ArticleDOI
TL;DR: In this article, the authors highlight the recent advancements and opportunities in the use of metal-free cooperative catalysts or initiators for polymerization reactions, including the ring-opening alternating copolymerization (ROAP) of epoxides with cyclic anhydrides.

35 citations


Cited by
More filters
Journal Article
TL;DR: Degradable biomaterials have been investigated for biomedical applications with novel materials constantly being developed to meet new challenges as mentioned in this paper, and a review summarizes the most recent advances in the field over the past four years, specifically highlighting new and interesting discoveries in tissue engineering and drug delivery applications.
Abstract: Utilization of polymers as biomaterials has greatly impacted the advancement of modern medicine. Specifically, polymeric biomaterials that are biodegradable provide the significant advantage of being able to be broken down and removed after they have served their function. Applications are wide ranging with degradable polymers being used clinically as surgical sutures and implants. To fit functional demand, materials with desired physical, chemical, biological, biomechanical, and degradation properties must be selected. Fortunately, a wide range of natural and synthetic degradable polymers has been investigated for biomedical applications with novel materials constantly being developed to meet new challenges. This review summarizes the most recent advances in the field over the past 4 years, specifically highlighting new and interesting discoveries in tissue engineering and drug delivery applications.

275 citations

Journal ArticleDOI
TL;DR: In this review, an overview of the recent studies concerning the production and evaluation of electrospun polymeric nanofibrous membranes for skin regenerative purposes is provided and their structural similarity with the extracellular matrix of normal skin is reviewed.

251 citations

Journal ArticleDOI
TL;DR: The basic principles of electrospinning, and the mechanisms and applications of Electrospun micro/nanofibers for delivery of small molecule drugs, proteins, and nucleic acids in the healthcare field are introduced.

219 citations

Journal ArticleDOI
TL;DR: The PVP-CIP/EC-AgNPs Janus fibers could be a promising candidate for effective wound dressings and paves a new way for creating Janus structure-based advanced functional nanomaterials.

177 citations

Journal ArticleDOI
TL;DR: Through balancing the Lewis acidity, Lewis basicity, and steric effects of LPs, LPP has shown several unique advantages or intriguing opportunities compared to other polymerization techniques and demonstrated its broad polar monomer scope, high activity, control or livingness, and complete chemo- or regioselectivity.
Abstract: The development of new or more sustainable, active, efficient, controlled, and selective polymerization reactions or processes continues to be crucial for the synthesis of important polymers or materials with specific structures or functions. In this context, the newly emerged polymerization technique enabled by main-group Lewis pairs (LPs), termed as Lewis pair polymerization (LPP), exploits the synergy and cooperativity between the Lewis acid (LA) and Lewis base (LB) sites of LPs, which can be employed as frustrated Lewis pairs (FLPs), interacting LPs (ILPs), or classical Lewis adducts (CLAs), to effect cooperative monomer activation as well as chain initiation, propagation, termination, and transfer events. Through balancing the Lewis acidity, Lewis basicity, and steric effects of LPs, LPP has shown several unique advantages or intriguing opportunities compared to other polymerization techniques and demonstrated its broad polar monomer scope, high activity, control or livingness, and complete chemo- or...

176 citations