S
Sreenivasan Ponnambalam
Researcher at University of Leeds
Publications - 129
Citations - 5139
Sreenivasan Ponnambalam is an academic researcher from University of Leeds. The author has contributed to research in topics: Vascular endothelial growth factor A & Receptor tyrosine kinase. The author has an hindex of 41, co-authored 117 publications receiving 4618 citations. Previous affiliations of Sreenivasan Ponnambalam include University of Birmingham & Lincoln's Inn.
Papers
More filters
Journal ArticleDOI
Biochemistry and cell biology of mammalian scavenger receptors
Jane E. Murphy,Philip R. Tedbury,Shervanthi Homer-Vanniasinkam,John H. Walker,Sreenivasan Ponnambalam +4 more
TL;DR: The current understanding of the scavenger receptor subclasses is reviewed with emphasis on their genetics, protein structure, biochemical properties, membrane trafficking, intracellular signalling and links to disease states.
Journal ArticleDOI
Scavenger Receptor Structure and Function in Health and Disease
Izma Abdul Zani,Sam L. Stephen,Nadeem A. Mughal,David Russell,Shervanthi Homer-Vanniasinkam,Stephen B. Wheatcroft,Sreenivasan Ponnambalam +6 more
TL;DR: Current understanding of SR structure and function implicated in health and disease is reviewed, including pathophysiological states including atherosclerosis, pathogen infections, immune surveillance, and cancer.
Journal ArticleDOI
Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.
Lorna C. Ewan,Helen M. Jopling,Haiyan Jia,Shweta Mittar,Azadeh Bagherzadeh,Gareth J. Howell,John H. Walker,Ian Zachary,Sreenivasan Ponnambalam +8 more
TL;DR: A mechanism whereby the transition of endothelial VEGFR2 from a constitutive recycling itinerary to a degradative pathway explains ligand‐activated receptor degradation in endothelial cells is proposed.
Journal ArticleDOI
The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease.
Sarah Dunn,Ravinder S. Vohra,Jane E. Murphy,Shervanthi Homer-Vanniasinkam,John H. Walker,Sreenivasan Ponnambalam +5 more
TL;DR: Transgenic mouse models for LOx-1 overexpression or gene knockout suggests that LOX-1 contributes to atherosclerotic plaque formation and progression and is a potential therapeutic target in heart attack and stroke prevention.
Journal ArticleDOI
Affimer proteins are versatile and renewable affinity reagents
Christian Tiede,Robert Bedford,Sophie J Heseltine,Gina A. Smith,Imeshi Wijetunga,Rebecca L. Ross,Danah AlQallaf,Ashley P.E. Roberts,Alexander Balls,Alistair Curd,Ruth E. Hughes,Heather L. Martin,Sarah R. Needham,Laura C. Zanetti-Domingues,Yashar Sadigh,Thomas P. Peacock,Anna A Tang,Naomi Gibson,Hannah F. Kyle,Geoffrey W. Platt,Nicola Ingram,Thomas Taylor,Louise Coletta,Iain W. Manfield,Margaret A. Knowles,Sandra M. Bell,Filomena Esteves,Azhar Maqbool,Raj Prasad,Mark J. Drinkhill,Robin S. Bon,Vikesh Patel,Sarah A. Goodchild,Marisa L. Martin-Fernandez,Raymond J. Owens,Joanne E. Nettleship,Michael E. Webb,Michael A. Harrison,Jonathan D. Lippiat,Sreenivasan Ponnambalam,Michelle Peckham,Alastair D. Smith,Paul Ko Ferrigno,Matthew Johnson,Michael J. McPherson,Darren C. Tomlinson +45 more
TL;DR: This work shows that Affimer proteins, as is the case for other alternative binding scaffolds, represent complementary affinity reagents to antibodies for various molecular and cell biology applications.