Sreeparna Majee

Bio: Sreeparna Majee is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: Nusselt number & Reynolds number. The author has an hindex of 5, co-authored 11 publications receiving 94 citations. Previous affiliations of Sreeparna Majee include Jadavpur University.

Modeling and simulation of blood flow with magnetic nanoparticles as carrier for targeted drug delivery in the stenosed artery

Abstract: A systematic study on targeted drug delivery is carried out in an unsteady flow of blood infused with magnetic nanoparticles with an aim to understand the flow pattern and nanoparticle aggregation in a diseased arterial segment having atherosclerosis. The magnetic NPs(nanoparticles) are supervised by a magnetic field, which is significant for the therapeutic treatment of arterial diseases, tumors, and cancer cells and removing blood clots. Coupled thermal energy equation has been modeled by considering the dissipation of energy that encounters due to the application of the magnetic field and the presence of high viscosity of blood. The simulation technique used to solve the mathematical model is vorticity-stream function formulations in the diseased artery. An elevation in SLP (Specific loss power) is noted in the aortic bloodstream when the agglomeration of nanoparticles is higher. This phenomenon has potential applications in the treatment of hyperthermia. The study focuses on the lowering of WSS (wall shear stress) with increasing particle concentration at the downstream of the stenosis, which depicts the vigorous flow circulation zone. These low shear stress regions prolong the residing time of the nanoparticles carrying drugs, which soaks up the LDL (Low-Density Lipoprotein) deposition. Moreover, an increase in NP concentration enhances the Nusselt number, which marks the increase of heat transfer from the arterial wall to the surrounding tissues to destroy tumor and cancer cells without affecting the healthy cells. The results have a significant influence on the study of medicine to treat arterial diseases such as atherosclerosis without the need for surgery, which can minimize the expenditures on cardiovascular treatments and post-surgical complications in patients.

Magnetic field interaction with blood flow and heat transfer through diseased artery having Abdominal Aortic Aneurysm

Abstract: Unsteady magnetohydrodynamic flow of blood and heat transfer characteristics are numerically simulated with an aim to understand the flow pattern in a diseased arterial segment having Abdominal Aortic Aneurysm (AAA). Thermal energy equation has been analyzed by considering dissipation of energy due to applied magnetic field and the viscosity of blood. Vorticity–stream function formulation is used for numerical simulation in the diseased artery. Different stages of enlargement of AAA is very significant in understanding the cause and progression of vascular diseases due to the formation of large vortex rings in the aneurysm region which interacts with the arterial wall. This lead to the generation of WSS which drastically differ by a magnitude of 37% in 50% AAA and 18% in 10% AAA in comparison with the value in a healthy abdominal aorta in the laminar flow. With increase in Reynolds number, mild AAA also become harmful as it exhibits higher WSS increase percentage in comparison with a healthy arterial segment. The vorticity, streamlines and temperature contours are plotted to have a better understanding of the flow characteristics. Qualitative as well as quantitative profiles of wall shear stress and Nusselt number are plotted and determined that both increases with the effect of magnetic field strength. Moreover, shear stress decreases with increasing Reynolds number whereas it increases with increasing size of the aneurysm. The area of low WSS region inside the aneurysm reduces when exposed to magnetic field strength and makes the arterial state less pathological. Furthermore, Nusselt number has an enhancing effect on both Reynolds number and Prandtl number. The results have significant bearing in medical sciences for assessing temperature rise during hyperthermic treatment of tumor and drug delivery system with magnetic nanoparticles in the diseased artery.

Mathematical Analysis on an Asymmetrical Wavy Motion of Blood under the Influence Entropy Generation with Convective Boundary Conditions

Abstract: In this article, we discuss the entropy generation on the asymmetric peristaltic propulsion of non-Newtonian fluid with convective boundary conditions. The Williamson fluid model is considered for the analysis of flow properties. The current fluid model has the ability to reveal Newtonian and non-Newtonian behavior. The present model is formulated via momentum, entropy, and energy equations, under the approximation of small Reynolds number and long wavelength of the peristaltic wave. A regular perturbation scheme is employed to obtain the series solutions up to third-order approximation. All the leading parameters are discussed with the help of graphs for entropy and temperature profiles. The irreversibility process is also discussed with the help of Bejan number. Streamlines are plotted to examine the trapping phenomena. Results obtained provide an excellent benchmark for further study on the entropy production with mass transfer and peristaltic pumping mechanism.