S
Sreya Tarafdar
Researcher at University of Pittsburgh
Publications - 3
Citations - 74
Sreya Tarafdar is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Proto-oncogene tyrosine-protein kinase Src & SH3 domain. The author has an hindex of 3, co-authored 3 publications receiving 64 citations.
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Journal ArticleDOI
Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment
TL;DR: The results suggest that in addition to serving as a kinase effector for Nef, Hck binding may reorganize the Nef dimer for functional interaction with other signaling partners.
Journal ArticleDOI
The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner.
TL;DR: Cell-based fluorescence complementation shows that HIV-1 Nef selectively interacts with Itk, Btk, and Bmx through their SH3 domains, providing the first evidence that Nef interacts with cytoplasmic tyrosine kinases of the Tec family and suggesting that Nf provides a mechanistic link between HIV- 1 and Itk signaling in the viral life cycle.
Journal ArticleDOI
Dynamics of the Tec-family tyrosine kinase SH3 domains.
Justin M. Roberts,Sreya Tarafdar,Raji E. Joseph,Amy H. Andreotti,Thomas E. Smithgall,John R. Engen,Thomas E. Wales +6 more
TL;DR: The studies are extended to the SH3 domains of the Tec family tyrosine kinases (Itk, Btk, Tec, TxK, Bmx) to augment the variety in dynamics observed in previousSH3 domains, which were found to be highly dynamic in solution by HX MS and unstructured by NMR.