Sridhara Janardhan

TL;DR: The present review highlights the recent role of ChoK in various types of Ras-dependent and Ras-independent carcinogenesis and stable expression of siRNAs and their high sequence specificity by RNAi mediated suppression of oncogenic ras in human pancreatic carcinoma, human melanomas and ovarian cancer.

TL;DR: The results that are obtained from 2D and 3D-QSAR studies may provide useful insights into the roles of various substitution patterns on the bis-pyridinium skeleton and may also help to design more potent compounds.

TL;DR: A series of novel quinazolinone hybrids synthesized by employing click chemistry and evaluated for anti-proliferative activities against MCF-7, HeLa and K562 cell lines revealed the G1 cell cycle arrest nature of these hybrids.

TL;DR: Common pharmacophore hypothesis (AAADDRR) among the best docked conformers of most potent compounds in a series of compounds and the most potent 9b, 9c, 9e compounds shared common active site with the Lisinopril binding site and retained the key active site residue interactions.

TL;DR: A new series of 1,2,3-triazole tethered chalcone acetamide derivatives have been synthesized in excellent yields and their structures were determined by analytical and spectral studies.