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Srikanta Kumar Padhy

Other affiliations: AIIMS, New Delhi
Bio: Srikanta Kumar Padhy is an academic researcher from L V Prasad Eye Institute. The author has contributed to research in topics: Visual acuity & Retinal detachment. The author has an hindex of 3, co-authored 29 publications receiving 24 citations. Previous affiliations of Srikanta Kumar Padhy include AIIMS, New Delhi.

Papers
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Journal ArticleDOI
TL;DR: In this paper, a case of bilateral acute-onset scotoma following SARS-CoV-2 infection in a 19-year-old girl attributed to the presence of paracentral acute middle maculopathy (PAMM).
Abstract: We herein report a case of bilateral acute-onset scotoma following SARS-CoV-2 infection in a 19-year-old girl attributed to the presence of paracentral acute middle maculopathy (PAMM). She was tested positive for SARS-CoV-2 infection 2 weeks prior by reverse transcription PCR testing and

24 citations

Journal ArticleDOI
TL;DR: OCT parameters such as changes in both CMT and SFCT along with subfoveal EZ damage can be predictive of disease resolution whereas changes in C MT and baseline SRF height correlate well with changes in BCVA through 12 months.
Abstract: Purpose To identify the factors predicting the visual and anatomical outcomes in eyes with central serous chorioretinopathy (CSCR) through 12 months. Methods Patients with diagnosis of CSCR, either acute or chronic, were included in this multicentric, retrospective study. Demographic factors; systemic risk factors; central macular thickness (CMT), subfoveal choroidal thickness (SFCT), linear extent of ellipsoid zone (EZ) and interdigitation zone damage on optical coherence tomography; details of leak on fluorescein angiography and indocyanine green angiography were included as predictors of anatomical and visual outcomes. Regression analysis was performed to correlate the changes in best corrected visual acuity (BCVA) and resolution of disease activity. Results A total of 231 eyes of 201 patients with a mean age (49.7±11.8 years) were analysed. A total of 97 and 134 eyes were classified as acute and chronic CSCR. BCVA (0.35±0.31 to 0.24±0.34; p Conclusion OCT parameters such as changes in both CMT and SFCT along with subfoveal EZ damage can be predictive of disease resolution whereas changes in CMT and baseline SRF height correlate well with changes in BCVA through 12 months.

19 citations

Journal ArticleDOI
TL;DR: A comprehensive review of the evidence thus far in support of gene therapy for LCA with voretigene neparvovec and the challenges that lie ahead for its translation for use in communities that differ much both genetically and economically are reported.
Abstract: Gene therapy has now evolved as the upcoming modality for management of many disorders, both inheritable and non-inheritable. Knowledge of genetics pertaining to a disease has therefore become paramount for physicians across most specialities. Inheritable retinal dystrophies (IRDs) are notorious for progressive and relentless vision loss, frequently culminating in complete blindness in both eyes. Leber's congenital amaurosis (LCA) is a typical example of an IRD that manifests very early in childhood. Research in gene therapy has led to the development and approval of voretigene neparvovec (VN) for use in patients of LCA with a deficient biallelic RPE65 gene. The procedure involves delivery of a recombinant virus vector that carries the RPE65 gene in the subretinal space. This comprehensive review reports the evidence thus far in support of gene therapy for LCA. We explore and compare the various gene targets including but not limited to RPE65, and discuss the choice of vector and method for ocular delivery. The review details the evolution of gene therapy with VN in a phased manner, concluding with the challenges that lie ahead for its translation for use in communities that differ much both genetically and economically.

12 citations

Journal ArticleDOI
TL;DR: The incidence of clinical EMB optic neuropathy was <2%, though subclinical damage in the form of increase in VER latency, and decrease in RNFL and GCIPL on OCT was seen in 46% eyes.
Abstract: Aims To evaluate incidence of toxic optic neuropathy in patients receiving ethambutol (EMB) for 6 months and to identify its early indicators. Methods We included 50 patients on anti-tubercular therapy (ATT) including EMB (HRE regimen) based on total body weight for 6 months. Best-corrected visual acuity (ETDRS), colour vision (Ishihara pseudo-isochromatic plates), contrast sensitivity (Pelli-Robson chart), Humphrey visual field analysis (HVF 30-2 SITA FAST), pattern visual evoked response (VER) and spectral-domain optical coherence tomography (SDOCT) for ganglion cell inner plexiform layer (GCIPL) and retinal nerve fibre layer (RNFL) analysis were assessed at baseline and at 2, 4 and 6 months after starting ATT. Results Mean age of the patients was 36.5±14.7 years with male:female ratio of 2.5:1. Mean daily dosage of EMB was 17.5±1.3 mg/kg/day. No significant change was observed in visual acuity, contrast sensitivity, color vision and mean or pattern SD on HVF at 6 months. Significant increase in VER latency of >2 SD (>125 ms) was observed in 46% eyes on follow-up indicating subclinical toxicity. Significant loss of mean RNFL (from 100.79±16.05 μm to 89.96±13.79 μm) and GCIPL thickness (from 83.1±5.60 μm to 79.85±6.45 μm) was observed at 6 months (p=0.001 for both). Patients with subclinical toxicity had significantly greater damage in temporal RNFL quadrant, supero-nasal and infero-nasal GCIPL sectors compared with others. Conclusion The incidence of clinical EMB optic neuropathy was

10 citations

Journal ArticleDOI
01 Nov 2021-Eye
TL;DR: Five babies (10 eyes) with atypically configured blebshaped posterior combined tractional and exudative retinal detachment in severe ROP, not yet reported in the literature are reported on.
Abstract: Retinal detachments associated with retinopathy of prematurity (ROP) are predominantly tractional [1], occasionally exudative [2], and rarely rhegmatogenous. The configuration of the tractional retinal detachment in ROP is guided by the fibrous tissue growing over the shunt at the junction of the vascularavascular retina [3] and the hyaloid stalk. Various tractional forces in the vitreous and previous treatment, if any, modulate these changes. The tractional forces can include ridge to ridge (trans-ridge), ridge to the retina, lens, hyaloid or ciliary body, etc. ROP detachment assumes a tent-shaped configuration when the tractional vectors from the contracting fibrovascular tissue over the ridge and around the optic disc predominate [1]. Isolated exudative detachment in ROP is often peripheral and can extend posteriorly but is relatively uncommon and can, at times, follow laser treatment. The detachment, occasionally, can have a bullous configuration when it is secondary to exudation. Rhegmatogenous retinal detachment, uncommon in active ROP, can happen in subjects with regressed cicatricial ROP at a later stage secondary to firmly attached contracting posterior hyaloid or fibrous tissue. In this article, we report a series of 5 babies (10 eyes) with atypically configured blebshaped posterior combined tractional and exudative retinal detachment in severe ROP, not yet reported in the literature (Medline search). The demographic details, mode, sequence, and timing of various interventions are summarized in Table 1. All babies had an eventful neonatal course and were treated at the NICUs with 100% oxygen supplementation using a hood or nasal prongs. The mean gestational age (GA), postmenstrual age (PMA), and birth weight (BW) were 29.8 (range 28–31) weeks, 36.3 (35–39) weeks, and 1252 (range 1060–1600) grams respectively. All babies had a delayed presentation, from 5 to 8 weeks after birth (Average:6.6 weeks).The detachments were-located posteriorly around the optic disc with attached but avascular periphery (Supplementary Table 1, Fig. 1, and Supplementary Figs. 1–4).The retinal vessels were scanty, disorganized, indistinct with a very posterior location in and around the bleb. Each eye received a combination of intravitreal bevacizumab half adult dose, visible area laser, and vitrectomy (lens sparing in 7 of 10 eyes) within a span of 1–3 weeks after presentation. Three eyes had good anatomical outcome, in 4 eyes; the disease was stabilized at cicatricial stage 4B, and it progressed to stage 5 ROP in 3 eyes The atypically configured bleb-shaped predominantly exudative and combined with focal tractional posterior only detachments in babies with ROP described here are not reported before (Medline search with keywords, ‘bleb or blister-like detachment’, ‘ROP’, ‘atypical detachment’, ‘configuration of Stage 4B ROP’, ‘combined ROP detachment’). These are different from classical tractional or Case1 was presented as a challenging case at the 3rd annual Indian Retinopathy of Prematurity (iROP) Society meet, July 21–22, 2018

7 citations


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Journal Article
TL;DR: In this paper, the authors measured the macular choroid thickness in normal eyes at different points using enhanced depth imaging (EDI) optical coherence tomography (OCT) and evaluated the association of choroidal thickness and age.
Abstract: PURPOSE To measure macular choroidal thickness in normal eyes at different points using enhanced depth imaging (EDI) optical coherence tomography (OCT) and to evaluate the association of choroidal thickness and age. DESIGN Retrospective, observational case series. METHODS EDI OCT images were obtained in patients without significant retinal or choroidal pathologic features. The images were obtained by positioning a spectral-domain OCT device close enough to the eye to acquire an inverted image. Seven sections were obtained within a 5 x 30-degree area centered at the fovea, with 100 scans averaged for each section. The choroid was measured from the outer border of the retinal pigment epithelium to the inner scleral border at 500-microm intervals of a horizontal section from 3 mm temporal to the fovea to 3 mm nasal to the fovea. Statistical analysis was performed to evaluate variations of choroidal thickness at each location and to correlate choroidal thickness and patient age. RESULTS The mean age of the 30 patients (54 eyes) was 50.4 years (range, 19 to 85 years), and 14 patients (46.7%) were female. The choroid was thickest underneath the fovea (mean, 287 microm; standard deviation, +/- 76 microm). Choroidal thickness decreased rapidly in the nasal direction and averaged 145 microm (+/- 57 microm) at 3 mm nasal to the fovea. Increasing age was correlated significantly with decreasing choroidal thickness at all points measured. Regression analysis suggested that the subfoveal choroidal thickness decreased by 15.6 microm for each decade of life. CONCLUSIONS Choroidal thickness seems to vary topographically within the posterior pole. The thickness of the choroid showed a negative correlation with age. The decrease in the thickness of the choroid may play a role in the pathophysiologic features of various age-related ocular conditions.

1,008 citations

Journal Article
TL;DR: In this paper, the NPHP6/CEP290 gene was found to represent a frequent cause of isolated Leber congenital amaurosis (LCA) in European descent.
Abstract: Leber congenital amaurosis (LCA) is the earliest and most severe retinal degeneration responsible for congenital blindness. Hitherto, 13 LCA genes have been mapped, nine of which have been identified. Recently, mutations in the NPHP6/CEP290 gene were shown to account for Joubert and Senior‐Loken syndromes and to represent a frequent cause of isolated LCA. All LCA patients shared an intronic mutation resulting in an aberrantly spliced transcript and low levels of wild‐type transcript that was believed to explain the absence of cerebellar and renal involvement in these patients. Here, we confirm the high frequency of NPHP6/CEP290 mutations in our series of LCA families hailing worldwide (22%). However, we show that conversely to other LCA genes, NPHP6 is involved in families of European descent only (38/38). A total of 24 different mutations were found, 23 of which are novel (one founder mutation in the North region of France). All mutations but two were either nonsense, frameshift, or splice‐site changes. The common NPHP6/CEP290 intronic mutation accounted for 43% (33/76) of all disease alleles. Twelve families did not carry this common intronic mutation. At least 10 out of them harboured two mutations expected to truncate the protein questioning the relevance of the assumption according to which the retinal‐restricted phenotype in LCA patient could be due to a residual NPHP6/CEP290 activity. Finally, we show that all patients were affected with the cone‐rod subtype of the disease whatever their NPHP6/CEP290 genotype. © 2007 Wiley‐Liss, Inc.

181 citations

01 Jan 1987
TL;DR: In this article, the authors describe recurrent episodes of visual loss occurring over a period of 26 years inpatient with optic disc drusen, but these have beensolitary events.
Abstract: Opticdiscdrusen maybeassociated witharcuate scotomas, constriction oftheperipheral visual field orrarely theloss ofcentral vision. Theprogression of visual field defects isusually insidious.' Thereare reports ofischaemic optic neuropathy occurring with drusen, butthese havebeensolitary events.2- This report documents recurrent episodes ofvisual loss occurring overaperiod of26years inapatient with optic disc drusen. CASE REPORT

37 citations

Journal ArticleDOI
TL;DR: In this article , a systematic review and meta-analysis was conducted to evaluate the occurrence of retinal microvasculopathy in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and who developed CoV-19.

35 citations

Journal ArticleDOI
TL;DR: In this paper , the authors reviewed current gene therapy products as well as gene therapies that may be approved in the near future, and also looked at ten-year changes in gene therapy clinical trials strategies, such as the use of vectors, target cells, transferred genes, and ex-vivo/invivo methods.

25 citations