Srinivasa Chakravarthy

TL;DR: It is argued that various motor symptoms in PD reflect dysfunction of neural structures responsible for action selection, motor sequencing, and coordination and execution of movement.

TL;DR: A spiking neuron network-model of SNc-STN-GPe system is developed, which shows that the interaction between SNc and STN involves a positive-feedback due to which, an initial loss ofSNc cells that crosses a threshold causes a runaway-effect, leading to an inexorable loss of Snc cells, strongly resembling the process of neurodegeneration.

TL;DR: In this article, the authors used FAPESP Research, Disseminations and Innovation Center for Neuromathematics (CNPq) for postdoctoral research.

TL;DR: A computational framework to build molecular connectivity maps by integrating mutated and differentially expressed genes of neurological and psychiatric diseases to determine its relationship with aging improves the understanding of the complex interactions that occur between neurological and Psychiatric diseases with aging.

TL;DR: It is suggested that energy-related book-keeping of the body at the physiological level is the common motif that links the many facets of dopamine and its functions, and regulates the processes of energy consumption and acquisition in the body.