S
Stanislaw Pikul
Researcher at Procter & Gamble
Publications - 82
Citations - 2311
Stanislaw Pikul is an academic researcher from Procter & Gamble. The author has contributed to research in topics: Matrix metalloproteinase inhibitor & Hydroxamic acid. The author has an hindex of 24, co-authored 81 publications receiving 2266 citations. Previous affiliations of Stanislaw Pikul include Harvard University & Polish Academy of Sciences.
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Tetrahedron report number 195 (R)- and (S)-2,3-0-isopropylideneglyceraldehyde in stereoselective organic synthesis
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Practical enantioselective Diels-Alder and aldol reactions using a new chiral controller system
TL;DR: In this paper, le complexe cyclique Al [−N(SO 2 CF 3 )(CHPh) 2 (CF 3 SO 2 )N-] R, R=i-Bu, CH 3
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Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors
Michael J. Janusz,E.B. Hookfin,Sandra A. Heitmeyer,J.F. Woessner,Anthony J. Freemont,Judith A. Hoyland,Kimberly K. Brown,Lily C. Hsieh,Neil Gregory Almstead,Biswanath De,Michael George Natchus,Stanislaw Pikul,Y.O. Taiwo +12 more
TL;DR: MMP inhibitors are partially protective against cartilage and subchondral bone damage induced by iodoacetate and support an important role for MMPs in mediating the joint damage in this model of arthritis.
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Design and synthesis of piperazine – based matrix metalloproteinase inhibitors
Cheng Menyan,Biswanath De,Stanislaw Pikul,Neil Gregory Almstead,Michael George Natchus,M.V. Anastasio,Sara Johnson Mcphail,Catherine E. Snider,Y.O. Taiwo,Longyin Chen,C. M. Dunaway,Fei Gu,Martin E. Dowty,Glen E. Mieling,Michael J. Janusz,S. Wang-Weigand +15 more
TL;DR: A new generation of cyclic matrix metalloproteinase (MMP) inhibitors derived from dl-piperazinecarboxylic acid has been described, with unique combination of all three elements producing inhibitor 20 with high affinity for MMPs 1, 3, 9, and 13.
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Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors.
Neil Gregory Almstead,Rimma Sandler Bradley,Stanislaw Pikul,Biswanath De,Michael George Natchus,Y.O. Taiwo,Fei Gu,Lisa E. Williams,Barbara A. Hynd,Michael J. Janusz,C. M. Dunaway,Glen E. Mieling +11 more
TL;DR: The synthesis and enzyme inhibition data for a series of thiazine- and thiazepine-based matrix metalloproteinase (MMP) inhibitors are described and the most potent series of inhibitors was obtained by modification of the amino acid D-penicillamine.