Stanley Cobb

Bio: Stanley Cobb is an academic researcher. The author has contributed to research in topics: Epilepsy & Cerebral circulation. The author has an hindex of 28, co-authored 93 publications receiving 2994 citations.

Neuropsychiatric aspects of Cushing's syndrome.

Abstract: SINCE Harvey Cushing's original description of a disease occurring in association with basophile adenoma of the pituitary gland, 1 it has become widely recognized that the characteristic clinical picture may occur not only in association with this specific anatomical lesion, but with a wider variety of pathological conditions. 2 Thus, it has become customary to speak of Cushing's syndrome rather than of Cushing's disease, and to apply the latter term, if at all, to those cases in which a basophile adenoma is demonstrable. Furthermore, it now seems clear that, whatever additional pathological changes are uncovered at autopsy, the clinical picture of both Cushing's disease and Cushing's syndrome can be regarded as the result of adrenocortical hyperfunction, whether neoplastic or hyperplastic in anatomical expression. As this study, therefore, is concerned principally with neuropsychiatric aspects, which are in themselves of a primary clinical nature, only the term Cushing's syndrome will be used

Preliminary observations on mental disturbances occurring in patients under therapy with cortisone and ACTH.

Abstract: IT HAS become increasingly apparent, during the past year, that mental disturbances are a not uncommon complication of therapy with cortisone and ACTH. It was initially observed that mild euphoria was frequent in patients undergoing this form of treatment, and more recently a variety of other mental abnormalities have been reported.1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 It is intended to describe in this paper a series of patients who developed varying degrees of mental disturbance while under treatment with these agents and to review briefly the possible etiologic factors and theoretical implications involved. The 10 cases histories to be presented are divided for descriptive purposes . . .

Disconnexion syndromes in animals and man

Abstract: As I have pointed out earlier, when I met Oliver Zangwill in 1961 at a meeting on dyslexia in Baltimore, he listened patiently to the exposition of my ideas on the significance of the cortico-cortical connections for the higher functions. A short time later, while on a trip to Boston, he suggested to me that I should prepare an extended account of these ideas. This paper would never have been written without Professor Zangwill’s urging, and I am grateful to him for having brought me to a more careful review of the older literature and a more precise statement of my own ideas. Although Russell Brain, who was then the editor of Brain, had some misgivings about the section on philosophical implications he agreed to take the manuscript unchanged.

Symptomatology and management of acute grief

Abstract: At first glance, acute grief would not seem to be a medical or psychiatric disorder in the strict sense of the word but rather a normal reaction to a distressing situation. However, the understanding of reactions to traumatic experiences whether or not they represent clear-cut neuroses has become of ever-increasing importance to the psychiatrist. Bereavement or the sudden cessation of social interaction seems to be of special interest because it is often cited among the alleged psychogenic factors in psychosomatic disorders. The enormous increase in grief reactions due to war casualties, furthermore, demands an evaluation of their probable effect on the mental and physical health of our population. The points to be made in this paper are as follows: i. Acute grief is a definite syndrome with psychological and somatic symptomatology. 2. This syndrome may appear immediately after a crisis; it may be delayed; it may be exaggerated or apparently al)sent. 3. In place of the typical syndrome there may appear distorted pictures, each of which represents one special aspect of the grief syndrome. 4. By appropriate techniques these distorted pictures can be successfully transformed into a normal grief reaction with resolution. Our observations comprise tot patients. Included are (i) psychoneurotic patients who lost a relative during the course of treatment, (2) relatives of patients who uied in the hospital, (3) bereaved disaster victims (Cocoanut Grove Fire) and their close relatives, ( ) relatives of members of the armed forces.

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*

Abstract: AS RECENTLY as 1900, tuberculosis, influenza, and pneumonia were the leading causes of death in our country (1). For the most part, however, these infectious diseases, as well as those of poor hygiene or undernutrition, no longer plague us. Instead, we succumb most frequently to heart disease and cancer, diseases of slow degeneration (1). Most of all, unlike so many in the generations before us, we are in a position to age. Regardless of what else occurs, we age, we become more constrained by the discrepancy between what we were and what we have become, and each step becomes harder. The goal in the study of aging is not to halt the process, because we can no more be cured of aging than of birth. The goal, instead, is to slow and soften the sharpest edges of the biological unraveling that constitutes aging. Over the past 5 yr, we have examined some of the sharpest edges of the pathology of aging. We have studied the capacity of aged organisms to respond appropriately to stress and the capacity of stress to...

Psychological aspects of natural language. use: our words, our selves.

Abstract: The words people use in their daily lives can reveal important aspects of their social and psychological worlds. With advances in computer technology, text analysis allows researchers to reliably and quickly assess features of what people say as well as subtleties in their linguistic styles. Following a brief review of several text analysis programs, we summarize some of the evidence that links natural word use to personality, social and situational fluctuations, and psychological interventions. Of particular interest are findings that point to the psychological value of studying particles—parts of speech that include pronouns, articles, prepositions, conjunctives, and auxiliary verbs. Particles, which serve as the glue that holds nouns and regular verbs together, can serve as markers of emotional state, social identity, and cognitive styles.

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis

Abstract: Over the past 5 yr, we have examined some of the sharpest edges of the pathology of aging. We have studied the capacity of aged organisms to respond appropriately to stress and the capacity of stre...