抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

The modern science of networks has brought significant advances to our understanding of complex systems. One of the most relevant features of graphs representing real systems is community structure, or clustering, i. e. the organization of vertices in clusters, with many edges joining vertices of the same cluster and comparatively few edges joining vertices of different clusters. Such clusters, or communities, can be considered as fairly independent compartments of a graph, playing a similar role like, e. g., the tissues or the organs in the human body. Detecting communities is of great importance in sociology, biology and computer science, disciplines where systems are often represented as graphs. This problem is very hard and not yet satisfactorily solved, despite the huge effort of a large interdisciplinary community of scientists working on it over the past few years. We will attempt a thorough exposition of the topic, from the definition of the main elements of the problem, to the presentation of most methods developed, with a special focus on techniques designed by statistical physicists, from the discussion of crucial issues like the significance of clustering and how methods should be tested and compared against each other, to the description of applications to real networks.

/pdf/community-detection-in-graphs-34rogm3r6p.pdf

Community detection in graphs

We will review some of the major results in random graphs and some of the more challenging open problems. We will cover algorithmic and structural questions. We will touch on newer models, including those related to the WWW.

Random graphs

One of the fundamental axioms of quantum mechanics is associated with the Hermiticity of physical observables 1 . In the case of the Hamiltonian operator, this requirement not only implies real eigenenergies but also guarantees probability conservation. Interestingly, a wide class of non-Hermitian Hamiltonians can still show entirely real spectra. Among these are Hamiltonians respecting parity‐time (PT) symmetry 2‐7 . Even though the Hermiticity of quantum observables was never in doubt, such concepts have motivated discussions on several fronts in physics, including quantum field theories 8 , nonHermitian Anderson models 9 and open quantum systems 10,11 , to mention a few. Although the impact of PT symmetry in these fields is still debated, it has been recently realized that optics can provide a fertile ground where PT-related notions can be implemented and experimentally investigated 12‐15 . In this letter we report the first observation of the behaviour of a PT optical coupled system that judiciously involves a complex index potential. We observe both spontaneous PT symmetry breaking and power oscillations violating left‐right symmetry. Our results may pave the way towards a new class of PT-synthetic materials with intriguing and unexpected properties that rely on non-reciprocal light propagation and tailored transverse energy flow. Before we introduce the concept of spacetime reflection in optics, we first briefly outline some of the basic aspects of this symmetry within the context of quantum mechanics. In general, a Hamiltonian HD p 2 =2mCV(x

/pdf/observation-of-parity-time-symmetry-in-optics-2qb17qrvql.pdf

Observation of parity–time symmetry in optics

The condition of self-adjointness ensures that the eigenvalues of a Hamiltonian are real and bounded below. Replacing this condition by the weaker condition of $\mathrm{PT}$ symmetry, one obtains new infinite classes of complex Hamiltonians whose spectra are also real and positive. These $\mathrm{PT}$ symmetric theories may be viewed as analytic continuations of conventional theories from real to complex phase space. This paper describes the unusual classical and quantum properties of these theories.

https://arxiv.org/pdf/physics/9712001.pdf

Real Spectra in Non-Hermitian Hamiltonians Having PT Symmetry

This paper proposes to broaden the canonical formulation of quantum mechanics. Ordinarily, one imposes the condition H†=H on the Hamiltonian, where † represents the mathematical operation of complex conjugation and matrix transposition. This conventional Hermiticity condition is sufficient to ensure that the Hamiltonian H has a real spectrum. However, replacing this mathematical condition by the weaker and more physical requirement H‡=H, where ‡ represents combined parity reflection and time reversal PT, one obtains new classes of complex Hamiltonians whose spectra are still real and positive. This generalization of Hermiticity is investigated using a complex deformation H=p2+x2(ix)e of the harmonic oscillator Hamiltonian, where e is a real parameter. The system exhibits two phases: When e⩾0, the energy spectrum of H is real and positive as a consequence of PT symmetry. However, when −1<e<0, the spectrum contains an infinite number of complex eigenvalues and a finite number of real, positive eigenvalues b...

http://www.physics.emory.edu/faculty/boettcher/Publications/papers/jmp40_2201.pdf

PT-symmetric quantum mechanics

We explore a new general-purpose heuristic for finding high-quality solutions to hard discrete optimization problems. The method, called extremal optimization, is inspired by self-organized criticality, a concept introduced to describe emergent complexity in physical systems. Extremal optimization successively updates extremely undesirable variables of a single suboptimal solution, assigning them new, random values. Large fluctuations ensue, efficiently exploring many local optima. We use extremal optimization to elucidate the phase transition in the 3-coloring problem, and we provide independent confirmation of previously reported extrapolations for the ground-state energy of {+-}J spin glasses in d=3 and 4 .

https://arxiv.org/pdf/cond-mat/0010337.pdf

Optimization with extremal dynamics.

http://www.physics.emory.edu/faculty/boettcher/Publications/papers/ai119_275.pdf

Nature's way of optimizing

A new two-parameter family of quasi-exactly solvable quartic polynomial potentials is introduced Heretofore, it was believed that the lowest-degree one-dimensional quasi-exactly solvable polynomial potential is sextic This belief is based on the assumption that the Hamiltonian must be Hermitian However, it has recently been discovered that there are huge classes of non-Hermitian, -symmetric Hamiltonians whose spectra are real, discrete, and bounded below Replacing hermiticity by the weaker condition of symmetry allows for new kinds of quasi-exactly solvable theories The spectra of this family of quartic potentials discussed here are also real, discrete and bounded below and the quasi-exact portion of the spectra consists of the lowest J eigenvalues These eigenvalues are the roots of a Jth-degree polynomial

Stefan Boettcher

Papers

Real Spectra in Non-Hermitian Hamiltonians Having PT Symmetry

PT-symmetric quantum mechanics

Optimization with extremal dynamics.

Nature's way of optimizing

Quasi-exactly solvable quartic potential