S
Stefano Bertuzzi
Researcher at National Institutes of Health
Publications - 21
Citations - 1639
Stefano Bertuzzi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Homeobox & LHX3. The author has an hindex of 14, co-authored 21 publications receiving 1567 citations. Previous affiliations of Stefano Bertuzzi include American Society for Cell Biology.
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Journal ArticleDOI
Specification of Pituitary Cell Lineages by the LIM Homeobox Gene Lhx3
Hui Z. Sheng,Alexander B. Zhadanov,Bedrich Mosinger,Tetsuya Fujii,Stefano Bertuzzi,Alexander Grinberg,Eric J. Lee,Sing-Ping Huang,Kathleen A. Mahon,Heiner Westphal +9 more
TL;DR: Targeted gene disruption in mice showed that Lhx3, a LIM homeobox gene expressed in the pituitsary throughout development, is essential for differentiation and proliferation of pituitary cell lineages, suggesting that a distinct, Lx3-independent ontogenetic pathway exists for the initial specification of this lineage.
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The other pigment cell: specification and development of the pigmented epithelium of the vertebrate eye.
TL;DR: While much has been learned about the molecular networks controlling RPE cell specification, key questions concerning the cell proliferative parameters in RPE and the subsequent morphogenetic events still need to be addressed.
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Expression pattern of the murine lim class homeobox gene lhx3 in subsets of neural and neuroendocrine tissues
TL;DR: The expression pattern of Lhx3 is well conserved between Xenopus and mouse, underscoring the functional importance of this gene as a regulator of development.
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Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF.
TL;DR: The results suggest that Mitf regulation in the developing eye is isoform-selective, both temporally and spatially, and that some isoforms, including H- and D-Mitf, are more crucial than others in effecting normal retina and pigment epithelium development.
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Measuring the Results of Science Investments
Julia Lane,Stefano Bertuzzi +1 more
TL;DR: Science agencies and research institutions are building the infrastructure to evaluate results of federal funding of scientific research and there is increasing pressure to document the results of these research investments in a scientific manner.