S
Stella S. Yu
Researcher at G. D. Searle & Company
Publications - 34
Citations - 2685
Stella S. Yu is an academic researcher from G. D. Searle & Company. The author has contributed to research in topics: Leukotriene B4 & Receptor antagonist. The author has an hindex of 14, co-authored 34 publications receiving 2581 citations.
Papers
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Journal ArticleDOI
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
T. D. Penning,John J. Talley,Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro,Roland S. Rogers,D. J. Rogier,Stella S. Yu,AndersonGD,E. G. Burton,J. N. Cogburn,Susan A. Gregory,Carol M. Koboldt,W E Perkins,Karen Seibert,A. W. Veenhuizen,Yan Y. Zhang,P. C. Isakson +22 more
TL;DR: 1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis, is identified.
Patent
Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
John J. Talley,Thomas D. Penning,Paul W. Collins,Donald J. Rogier,James W. Malecha,Julie M. Miyashiro,Stephen R. Bertenshaw,Ish K. Khanna,Matthew J. Graneto,Roland S. Rogers,Jeffery S. Carter,Stephen H. Docter,Stella S. Yu +12 more
TL;DR: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders in this paper, where the compounds of particular interest are defined by formula (II).
Journal ArticleDOI
Improved Procedure for the Reduction of N-Acyloxazolidinones
Thomas D. Penning,Stevan W. Djuric,Richard A. Haack,V. J. Kalish,Julie M. Miyashiro,Bruce W. Rowell,Stella S. Yu +6 more
TL;DR: Lithium borohydride in the presence of one equivalent of water has been found to be an efficient agent for the reduction of sterically hindered acyloxazolidinones to the corresponding primary alcohol as mentioned in this paper.
Patent
1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
TL;DR: In this article, a class of 1,3,5-substituted pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis.
Patent
Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
TL;DR: These compounds are selective antagonists of leukotriene B₄(LTB) with little or no antagonism against leukotide-based drugs and are useful anti-inflammatory agents for treating inflammatory bowel disease, rheumatoid arthritis, gout and psoriasis as mentioned in this paper.