S
Stephan J. Sigrist
Researcher at Free University of Berlin
Publications - 188
Citations - 15437
Stephan J. Sigrist is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Active zone & Synaptic vesicle. The author has an hindex of 57, co-authored 172 publications receiving 13360 citations. Previous affiliations of Stephan J. Sigrist include Max Planck Society & University of Bayreuth.
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Journal ArticleDOI
Oxygen stress: a regulator of apoptosis in yeast.
Frank Madeo,Eleonore Fröhlich,Martin Ligr,Martin Grey,Stephan J. Sigrist,Dieter H. Wolf,Kai-Uwe Fröhlich +6 more
TL;DR: It is found that apoptosis can be induced in the yeast Saccharomyces cerevisiae by depletion of glutathione or by low external doses of H2O2, and oxygen radicals to accumulate in the cell, whereas radical depletion or hypoxia prevents apoptosis.
Journal ArticleDOI
A Caspase-Related Protease Regulates Apoptosis in Yeast.
Frank Madeo,Eva Herker,Corinna Maldener,Silke Wissing,Stephan Lächelt,Mark Herlan,Markus Fehr,Kirsten Lauber,Stephan J. Sigrist,Sebastian Wesselborg,Kai-Uwe Fröhlich +10 more
TL;DR: It is concluded that Yor197w indeed functions as a bona fide caspase in yeast and the name Yeast Caspase-1 is proposed, pointing to a physiological role in elimination of overaged cells.
Journal ArticleDOI
Bruchpilot, a Protein with Homology to ELKS/CAST, Is Required for Structural Integrity and Function of Synaptic Active Zones in Drosophila
Dhananjay A. Wagh,Tobias M. Rasse,Esther Asan,Alois Hofbauer,Isabell Schwenkert,Heike Dürrbeck,Sigrid Buchner,Marie-Christine Dabauvalle,Manuela Schmidt,Gang Qin,Carolin Wichmann,Robert J. Kittel,Stephan J. Sigrist,Erich Buchner +13 more
TL;DR: It is proposed that Bruchpilot protein (BRP) is critical for intact AZ structure and normal-evoked neurotransmitter release at chemical synapses of Drosophila.
Journal ArticleDOI
Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release
Robert J. Kittel,Carolin Wichmann,Tobias M. Rasse,Wernher Fouquet,Manuela Schmidt,Andreas Schmid,Dhananjay A. Wagh,Christian Pawlu,Robert R. Kellner,Katrin I. Willig,Stefan W. Hell,Erich Buchner,Manfred Heckmann,Stephan J. Sigrist +13 more
TL;DR: Drosophila coiled-coil domain protein Bruchpilot-like proteins seem to establish proximity between Ca2+ channels and vesicles to allow efficient transmitter release and patterned synaptic plasticity.
Journal ArticleDOI
Cardioprotection and lifespan extension by the natural polyamine spermidine
Tobias Eisenberg,Mahmoud Abdellatif,Sabrina Schroeder,Uwe Primessnig,Uwe Primessnig,Slaven Stekovic,Tobias Pendl,Alexandra Harger,Alexandra Harger,Julia Schipke,Andreas Zimmermann,Albrecht Schmidt,Mingming Tong,Christoph Ruckenstuhl,Christopher Dammbrueck,Angelina S. Gross,Viktoria Herbst,Christoph Magnes,Gert Trausinger,Sophie H. Narath,Andreas Meinitzer,Zehan Hu,Zehan Hu,Alexander H. Kirsch,Kathrin Eller,Didac Carmona-Gutierrez,Sabrina Büttner,Sabrina Büttner,Federico Pietrocola,Oskar Knittelfelder,Emilie Schrepfer,Patrick Rockenfeller,Patrick Rockenfeller,Corinna Simonini,Alexandros Rahn,Marion Horsch,Kristin Moreth,Johannes Beckers,Helmut Fuchs,Valerie Gailus-Durner,Frauke Neff,Dirk Janik,Birgit Rathkolb,Jan Rozman,Martin Hrabé de Angelis,Tarek Moustafa,Tarek Moustafa,Guenter Haemmerle,Manuel Mayr,Peter Willeit,Peter Willeit,Marion von Frieling-Salewsky,Burkert Pieske,Burkert Pieske,Luca Scorrano,Thomas R. Pieber,Thomas R. Pieber,Raimund Pechlaner,Johann Willeit,Stephan J. Sigrist,Stephan J. Sigrist,Wolfgang A. Linke,Christian Mühlfeld,Junichi Sadoshima,Joern Dengjel,Joern Dengjel,Stefan Kiechl,Guido Kroemer,Simon Sedej,Frank Madeo +69 more
TL;DR: It is shown that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice, and suggests a new and feasible strategy for protection against cardiovascular disease.