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Stephan W. Grill
Researcher at Max Planck Society
Publications - 118
Citations - 13243
Stephan W. Grill is an academic researcher from Max Planck Society. The author has contributed to research in topics: Chemistry & Cell cortex. The author has an hindex of 52, co-authored 109 publications receiving 10830 citations. Previous affiliations of Stephan W. Grill include European Bioinformatics Institute & Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
Avinash Patel,Hyun O. Lee,Louise Jawerth,Shovamayee Maharana,Marcus Jahnel,Marco Y. Hein,Stoyno S. Stoynov,Julia Mahamid,Shambaditya Saha,Titus M. Franzmann,Andrej Pozniakovski,Ina Poser,Nicola Maghelli,Loic Royer,Martin Weigert,Eugene W. Myers,Stephan W. Grill,David N. Drechsel,Anthony A. Hyman,Simon Alberti +19 more
TL;DR: It is proposed that liquid-like compartments carry the trade-off between functionality and risk of aggregation and that aberrant phase transitions within liquid- like compartments lie at the heart of ALS and, presumably, other age-related diseases.
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Lattice Light Sheet Microscopy: Imaging Molecules to Embryos at High Spatiotemporal Resolution
Bi-Chang Chen,Wesley R. Legant,Kai Wang,Lin Shao,Daniel E. Milkie,Michael W. Davidson,Chris Janetopoulos,Xufeng S. Wu,John A. Hammer,Zhe Liu,Brian P. English,Yuko Mimori-Kiyosue,Daniel P. Romero,Alex T. Ritter,Alex T. Ritter,Jennifer Lippincott-Schwartz,Lillian K. Fritz-Laylin,R. Dyche Mullins,Diana M. Mitchell,Joshua N. Bembenek,Anne-Cécile Reymann,Ralph Böhme,Stephan W. Grill,Jennifer T. Wang,Geraldine Seydoux,U. Serdar Tulu,Daniel P. Kiehart,Eric Betzig +27 more
TL;DR: A new microscope using ultrathin light sheets derived from two-dimensional optical lattices is developed, demonstrating the performance advantages of lattice light-sheet microscopy compared with previous techniques and highlighted phenomena that, when seen at increased spatiotemporal detail, may hint at previously unknown biological mechanisms.
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Phase separation of a yeast prion protein promotes cellular fitness
Titus M. Franzmann,Marcus Jahnel,Marcus Jahnel,Andrei Pozniakovsky,Julia Mahamid,Alex S. Holehouse,Elisabeth Nüske,Doris Richter,Wolfgang Baumeister,Stephan W. Grill,Stephan W. Grill,Rohit V. Pappu,Anthony A. Hyman,Simon Alberti +13 more
TL;DR: It is shown that the prion domain of Sup35 drives the reversible phase separation of the translation termination factor into biomolecular condensates, which are distinct and different from fibrillar amyloid-like prion particles.
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Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo
TL;DR: A mechanism for generating asymmetry in spindle positioning is suggested by varying the net pulling force that acts on each spindle pole, thus allowing for the generation of daughter cells with different sizes.
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Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows
TL;DR: The physical requirements of large-scale intracellular cortical flow that ensure the efficient polarization of the C. elegans zygote are revealed, including a gradient in actomyosin contractility to drive flow and a sufficiently large viscosity of the cortex to allow flow to be long-ranged.