Stephen B. Dunnett

TL;DR: The purpose of the present review is to summarize the current knowledge of the diversity and neurochemical features of the nine dopamine-containing neuronal cell groups in the mammalian brain, their distinctive cellular properties, and their ability to regulate their dopaminergic transmitter machinery in response to altered functional demands and aging.

TL;DR: R6/2 mice show measurable deficits in motor behavior that begin subtly and increase progressively until death and indicate that they may be useful for evaluating therapeutic strategies for HD, particularly those aimed at reducing the severity of motor symptoms or slowing the course of the disease.

TL;DR: The results suggest that no simple relationship exists between LTP, spatial learning, and immediate early gene induction, and that immediate early genes can be differentially activated within the central nervous system.

TL;DR: A novel reaching test for the rat has been developed to assess the independent use of forelimbs in skilled reaching and grasping tasks and the simplicity of the apparatus permits many animals to be tested concurrently.

TL;DR: This new understanding of the pathogenesis of Parkinson's disease now offers novel prospects for therapy based on targeted neuroprotection of vulnerable neurons and effective strategies for their replacement.