S
Stephen C. Whisson
Researcher at James Hutton Institute
Publications - 57
Citations - 5520
Stephen C. Whisson is an academic researcher from James Hutton Institute. The author has contributed to research in topics: Phytophthora infestans & Effector. The author has an hindex of 28, co-authored 52 publications receiving 4883 citations. Previous affiliations of Stephen C. Whisson include University of Dundee & Scottish Crop Research Institute.
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Journal ArticleDOI
Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans.
Brian J. Haas,Sophien Kamoun,Sophien Kamoun,Michael C. Zody,Michael C. Zody,Rays H. Y. Jiang,Rays H. Y. Jiang,Robert E. Handsaker,Liliana M. Cano,Manfred Grabherr,Chinnappa D. Kodira,Chinnappa D. Kodira,Sylvain Raffaele,Trudy Torto-Alalibo,Trudy Torto-Alalibo,Tolga O. Bozkurt,Audrey M. V. Ah-Fong,Lucia Alvarado,Vicky L. Anderson,Miles R. Armstrong,Anna O. Avrova,Laura Baxter,Jim Beynon,Petra C. Boevink,Stephanie R. Bollmann,Jorunn I. B. Bos,Vincent Bulone,Guohong Cai,Cahid Cakir,James C. Carrington,Megan Chawner,Lucio Conti,Stefano Costanzo,Richard Ewan,Noah Fahlgren,Michael A. Fischbach,Johanna Fugelstad,Eleanor M. Gilroy,Sante Gnerre,Pamela J. Green,Laura J. Grenville-Briggs,John Griffith,Niklaus J. Grünwald,Karolyn Horn,Neil R. Horner,Chia-Hui Hu,Edgar Huitema,Dong-Hoon Jeong,Alexandra M. E. Jones,Jonathan D. G. Jones,Richard W. Jones,Elinor K. Karlsson,Sridhara G. Kunjeti,Kurt Lamour,Zhenyu Liu,Li-Jun Ma,Dan MacLean,Marcus C. Chibucos,Hayes McDonald,Jessica McWalters,Harold J. G. Meijer,William Morgan,Paul Morris,Carol A. Munro,Keith O'Neill,Keith O'Neill,Manuel D. Ospina-Giraldo,Andrés Pinzón,Leighton Pritchard,Bernard H Ramsahoye,Qinghu Ren,Silvia Restrepo,Sourav Roy,Ari Sadanandom,Alon Savidor,Sebastian Schornack,David C. Schwartz,Ulrike Schumann,Ben Schwessinger,Lauren Seyer,Ted Sharpe,Cristina Silvar,Jing Song,David J. Studholme,Sean M. Sykes,Marco Thines,Marco Thines,Peter J. I. van de Vondervoort,Vipaporn Phuntumart,Stephan Wawra,R. Weide,Joe Win,Carolyn A. Young,Shiguo Zhou,William E. Fry,Blake C. Meyers,Pieter van West,Jean B. Ristaino,Francine Govers,Paul R. J. Birch,Stephen C. Whisson,Howard S. Judelson,Chad Nusbaum +102 more
TL;DR: The sequence of the P. infestans genome is reported, which at ∼240 megabases (Mb) is by far the largest and most complex genome sequenced so far in the chromalveolates and probably plays a crucial part in the rapid adaptability of the pathogen to host plants and underpins its evolutionary potential.
Journal ArticleDOI
A translocation signal for delivery of oomycete effector proteins into host plant cells
Stephen C. Whisson,Petra C. Boevink,Lucy N. Moleleki,Anna O. Avrova,Juan G. Morales,Eleanor M. Gilroy,Miles R. Armstrong,Severine Grouffaud,Severine Grouffaud,Pieter van West,Sean Chapman,Ingo Hein,Ian K. Toth,Leighton Pritchard,Paul R. J. Birch +14 more
TL;DR: Functional analyses of two motifs, RXLR and EER, present in translocated oomycete effectors are reported, showing that RXLR-EER-encoding genes are transcriptionally upregulated during infection and 425 potential genes encoding secreted RXLR/EER class proteins in the P. infestans genome are identified.
Journal ArticleDOI
An ancestral oomycete locus contains late blight avirulence gene Avr3a, encoding a protein that is recognized in the host cytoplasm
Miles R. Armstrong,Stephen C. Whisson,Leighton Pritchard,Leighton Pritchard,Jorunn I. B. Bos,Eduard Venter,Anna O. Avrova,Anne P. Rehmany,Ulrike Böhme,Karen Brooks,Inna Cherevach,N. Hamlin,Brian White,Audrey Fraser,Angela Lord,Michael A. Quail,Carol Churcher,Neil Hall,Matthew Berriman,Sanwen Huang,Sophien Kamoun,Jim Beynon,Paul R. J. Birch +22 more
TL;DR: The oomycete Phytophthora infestans causes late blight, the potato disease that precipitated the Irish famines in 1846 and 1847, and it is suggested that Avr3a has undergone gene duplication and that an allele evading recognition by R3a arose under positive selection.
Journal ArticleDOI
Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1.
Jorunn I. B. Bos,Miles R. Armstrong,Eleanor M. Gilroy,Petra C. Boevink,Ingo Hein,Rosalind M. Taylor,Rosalind M. Taylor,Tian Zhendong,Tian Zhendong,Stefan Engelhardt,Ramesh R. Vetukuri,Ramesh R. Vetukuri,Brian Harrower,Christina Dixelius,Glenn J. Bryan,Ari Sadanandom,Stephen C. Whisson,Sophien Kamoun,Paul R. J. Birch +18 more
TL;DR: The data provide genetic evidence that AVR3a is an essential virulence factor that targets and stabilizes the plant E3 ligase CMPG1, potentially to prevent host cell death during the biotrophic phase of infection.
Journal ArticleDOI
An RxLR Effector from Phytophthora infestans Prevents Re-localisation of Two Plant NAC Transcription Factors from the Endoplasmic Reticulum to the Nucleus
Hazel McLellan,Petra C. Boevink,Miles R. Armstrong,Leighton Pritchard,Leighton Pritchard,Sonia Gomez,Sonia Gomez,Juan Carlos Correa Morales,Stephen C. Whisson,Jim Beynon,Paul R. J. Birch +10 more
TL;DR: The identification of two putative membrane-associated NAC transcription factors (TF) as the host targets of the RxLR effector PITG_03192 (Pi03192) is described, revealing a novel effector mode-of-action to promote disease progression.