S
Stephen E. Epstein
Researcher at MedStar Washington Hospital Center
Publications - 101
Citations - 21552
Stephen E. Epstein is an academic researcher from MedStar Washington Hospital Center. The author has contributed to research in topics: Coronary artery disease & Genome-wide association study. The author has an hindex of 57, co-authored 101 publications receiving 19623 citations. Previous affiliations of Stephen E. Epstein include National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study
Benjamin F. Voight,Benjamin F. Voight,Benjamin F. Voight,Gina M. Peloso,Gina M. Peloso,Marju Orho-Melander,Ruth Frikke-Schmidt,Maja Barbalić,Majken K. Jensen,George Hindy,Hilma Holm,Eric L. Ding,Toby Johnson,Heribert Schunkert,Nilesh J. Samani,Nilesh J. Samani,Robert Clarke,Jemma C. Hopewell,John F. Thompson,Mingyao Li,Gudmar Thorleifsson,Christopher Newton-Cheh,Kiran Musunuru,Kiran Musunuru,James P. Pirruccello,James P. Pirruccello,Danish Saleheen,Li Chen,Alexandre F.R. Stewart,Arne Schillert,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Gudmundur Thorgeirsson,Sonia S. Anand,James C. Engert,Thomas M. Morgan,John A. Spertus,Monika Stoll,Klaus Berger,Nicola Martinelli,Domenico Girelli,Pascal P. McKeown,Christopher Patterson,Stephen E. Epstein,Joseph M. Devaney,Mary Susan Burnett,Vincent Mooser,Samuli Ripatti,Ida Surakka,Markku S. Nieminen,Juha Sinisalo,Marja-Liisa Lokki,Markus Perola,Aki S. Havulinna,Ulf de Faire,Bruna Gigante,Erik Ingelsson,Tanja Zeller,Philipp S. Wild,Paul I.W. de Bakker,Olaf H. Klungel,Anke-Hilse Maitland-van der Zee,Bas J M Peters,Anthonius de Boer,Diederick E. Grobbee,Pieter Willem Kamphuisen,Vera H.M. Deneer,Clara C. Elbers,N. Charlotte Onland-Moret,Marten H. Hofker,Cisca Wijmenga,W. M. Monique Verschuren,Jolanda M. A. Boer,Yvonne T. van der Schouw,Asif Rasheed,Philippe M. Frossard,Serkalem Demissie,Serkalem Demissie,Cristen J. Willer,Ron Do,Jose M. Ordovas,Jose M. Ordovas,Gonçalo R. Abecasis,Michael Boehnke,Karen L. Mohlke,Mark J. Daly,Mark J. Daly,Candace Guiducci,Noël P. Burtt,Aarti Surti,Elena Gonzalez,Shaun Purcell,Shaun Purcell,Stacey Gabriel,Jaume Marrugat,John F. Peden,Jeanette Erdmann,Patrick Diemert,Christina Willenborg,Inke R. König,Marcus Fischer,Christian Hengstenberg,Andreas Ziegler,Ian Buysschaert,Diether Lambrechts,Frans Van de Werf,Keith A.A. Fox,Nour Eddine El Mokhtari,Diana Rubin,Jürgen Schrezenmeir,Stefan Schreiber,Arne Schäfer,John Danesh,Stefan Blankenberg,Robert Roberts,Ruth McPherson,Hugh Watkins,Alistair S. Hall,Kim Overvad,Eric B. Rimm,Eric Boerwinkle,Anne Tybjærg-Hansen,L. Adrienne Cupples,L. Adrienne Cupples,Muredach P. Reilly,Olle Melander,Pier Mannuccio Mannucci,Diego Ardissino,David S. Siscovick,Roberto Elosua,Kari Stefansson,Kari Stefansson,Christopher J. O'Donnell,Christopher J. O'Donnell,Veikko Salomaa,Daniel J. Rader,Leena Peltonen,Leena Peltonen,Stephen M. Schwartz,David Altshuler,Sekar Kathiresan +140 more
TL;DR: In this paper, a Mendelian randomisation analysis was performed to compare the effect of HDL cholesterol, LDL cholesterol, and genetic score on risk of myocardial infarction.
Journal ArticleDOI
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
Majid Nikpay,Anuj Goel,Won H-H.,Leanne M. Hall,Christina Willenborg,Stavroula Kanoni,Danish Saleheen,Theodosios Kyriakou,Christopher P. Nelson,Christopher P. Nelson,Jemma C. Hopewell,Tom R. Webb,Tom R. Webb,Lingyao Zeng,Abbas Dehghan,Maris Alver,Sebastian M. Armasu,Kirsi Auro,Kirsi Auro,Andrew Bjonnes,Daniel I. Chasman,Shufeng Chen,Ian Ford,Nora Franceschini,Christian Gieger,Christopher Grace,Stefan Gustafsson,Jie Huang,Hwang S-J.,Yun Kyoung Kim,Marcus E. Kleber,King Wai Lau,Xiangfeng Lu,Yingchang Lu,Lyytikäinen L-P.,Evelin Mihailov,Alanna C. Morrison,Natalia Pervjakova,Natalia Pervjakova,Natalia Pervjakova,Liming Qu,Lynda M. Rose,Elias Salfati,Richa Saxena,Markus Scholz,Albert V. Smith,Emmi Tikkanen,André G. Uitterlinden,Xueli Yang,Weihua Zhang,Wei Zhao,M. De Andrade,P. De Vries,N. R. van Zuydam,N. R. van Zuydam,Sonia S. Anand,Lars Bertram,Frank Beutner,George Dedoussis,Philippe M. Frossard,Dominique Gauguier,Alison H. Goodall,Omri Gottesman,Marc Haber,Han B-G.,Shapour Jalilzadeh,Thorsten Kessler,Inke R. König,Lars Lannfelt,Wolfgang Lieb,Lars Lind,Cecilia M. Lindgren,Lokki M-L.,Lokki M-L.,Patrik K. E. Magnusson,Nadeem Hayyat Mallick,Narinder K. Mehra,Thomas Meitinger,Memon F-U-R.,Andrew P. Morris,Andrew P. Morris,Markku S. Nieminen,Nancy L. Pedersen,Annette Peters,Loukianos S. Rallidis,Adil Rasheed,M Samuel,Svati H. Shah,Juha Sinisalo,Kathleen Stirrups,Stella Trompet,Ligui Wang,Ligui Wang,Khan Shah Zaman,Diego Ardissino,Eric Boerwinkle,Ingrid B. Borecki,Erwin P. Bottinger,Julie E. Buring,John C. Chambers,Rory Collins,L. A. Cupples,L. A. Cupples,John Danesh,Ilja Demuth,Roberto Elosua,Stephen E. Epstein,Tõnu Esko,Mary F. Feitosa,Oscar H. Franco,MariaGrazia Franzosi,Christopher B. Granger,Dongfeng Gu,Vilmundur Gudnason,Alistair S. Hall,Anders Hamsten,Tamara B. Harris,Stanley L. Hazen,Christian Hengstenberg,Albert Hofman,Erik Ingelsson,Carlos Iribarren,J W Jukema,Pekka J. Karhunen,Kim B-J.,Jaspal S. Kooner,Iftikhar J. Kullo,Terho Lehtimäki,Loos Rjf.,Olle Melander,Andres Metspalu,Winfried März,Winfried März,Winfried März,Colin N. A. Palmer,Markus Perola,Markus Perola,Markus Perola,Thomas Quertermous,Daniel J. Rader,Paul M. Ridker,Samuli Ripatti,Samuli Ripatti,Robert Roberts,Veikko Salomaa,Dharambir K. Sanghera,Stephen M. Schwartz,Udo Seedorf,Alexandre F.R. Stewart,David J. Stott,Joachim Thiery,Pierre Zalloua,Christopher J. O'Donnell,Christopher J. O'Donnell,Muredach P. Reilly,Themistocles L. Assimes,John R. Thompson,Jeanette Erdmann,Robert Clarke,Hugh Watkins,Sekar Kathiresan,Ruth McPherson,Panos Deloukas,Panos Deloukas,Heribert Schunkert,Nilesh J. Samani,Nilesh J. Samani,Martin Farrall +167 more
TL;DR: This article conducted a meta-analysis of coronary artery disease (CAD) cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 millions low-frequency (0.005 < MAF < 0.5) variants.
Journal ArticleDOI
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Heribert Schunkert,Inke R. König,Sekar Kathiresan,Muredach P. Reilly,Themistocles L. Assimes,Hilma Holm,Michael Preuss,Alexandre F.R. Stewart,Maja Barbalić,Christian Gieger,Devin Absher,Zouhair Aherrahrou,Hooman Allayee,David Altshuler,Sonia S. Anand,Karl Andersen,Jeffrey L. Anderson,Diego Ardissino,Stephen G. Ball,Anthony J. Balmforth,Timothy A. Barnes,Diane M. Becker,Lewis C. Becker,Klaus Berger,Joshua C. Bis,S. Matthijs Boekholdt,Eric Boerwinkle,Peter S. Braund,Morris J. Brown,Mary Susan Burnett,Ian Buysschaert,John F. Carlquist,Li Chen,Sven Cichon,Veryan Codd,Robert W. Davies,George Dedoussis,Abbas Dehghan,Serkalem Demissie,Joseph M. Devaney,Patrick Diemert,Ron Do,Angela Doering,Sandra Eifert,Nour Eddine El Mokhtari,Stephen G. Ellis,Roberto Elosua,James C. Engert,Stephen E. Epstein,Ulf de Faire,Marcus Fischer,Aaron R. Folsom,Jennifer Freyer,Bruna Gigante,Domenico Girelli,Solveig Gretarsdottir,Vilmundur Gudnason,Jeffrey R. Gulcher,Eran Halperin,Naomi Hammond,Stanley L. Hazen,Albert Hofman,Benjamin D. Horne,Thomas Illig,Carlos Iribarren,Gregory T. Jones,J. Wouter Jukema,Michael A. Kaiser,Lee M. Kaplan,John J.P. Kastelein,Kay-Tee Khaw,Joshua W. Knowles,G. Kolovou,Augustine Kong,Reijo Laaksonen,Diether Lambrechts,Karin Leander,Guillaume Lettre,Mingyao Li,Wolfgang Lieb,Christina Loley,Andrew J. Lotery,Pier Mannuccio Mannucci,Seraya Maouche,Nicola Martinelli,Pascal P. McKeown,Christa Meisinger,Thomas Meitinger,Olle Melander,Pier Angelica Merlini,Vincent Mooser,Thomas M. Morgan,Thomas W. Mühleisen,Joseph B. Muhlestein,Thomas Münzel,Kiran Musunuru,Janja Nahrstaedt,Christopher P. Nelson,Markus M. Nöthen,Oliviero Olivieri,Riyaz S. Patel,Christopher Patterson,Annette Peters,Flora Peyvandi,Liming Qu,Arshed A. Quyyumi,Daniel J. Rader,Loukianos S. Rallidis,Catherine M. Rice,Frits R. Rosendaal,Diana Rubin,Veikko Salomaa,M. Lourdes Sampietro,M. S. Sandhu,Eric E. Schadt,Arne Scḧsignfer,Arne Schillert,Stefan Schreiber,Jürgen Schrezenmeir,Stephen M. Schwartz,David S. Siscovick,Mohan U. Sivananthan,Suthesh Sivapalaratnam,Albert V. Smith,Tamara B. Smith,Jaapjan D. Snoep,Nicole Soranzo,John A. Spertus,Klaus Stark,Kathy Stirrups,Monika Stoll,W.H. Wilson Tang,Stephanie Tennstedt,Gudmundur Thorgeirsson,Gudmar Thorleifsson,Maciej Tomaszewski,André G. Uitterlinden,Andre M. van Rij,Benjamin F. Voight,Nicholas J. Wareham,George A. Wells,H.-Erich Wichmann,Philipp S. Wild,Christina Willenborg,Jaqueline C M Witteman,Benjamin J. Wright,Shu Ye,Tanja Zeller,Andreas Ziegler,François Cambien,Alison H. Goodall,L. Adrienne Cupples,Thomas Quertermous,Winfried Mäsignrz,Christian Hengstenberg,Stefan Blankenberg,Willem H. Ouwehand,Alistair S. Hall,Panos Deloukas,John R. Thompson,Kari Stefansson,Robert Roberts,Unnur Thorsteinsdottir,Christopher J. O'Donnell,Ruth McPherson,Jeanette Erdmann,Nilesh J. Samani +166 more
TL;DR: This paper performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals.
Journal ArticleDOI
Large-scale association analysis identifies new risk loci for coronary artery disease
Panos Deloukas,Stavroula Kanoni,Christina Willenborg,Martin Farrall,Themistocles L. Assimes,John R. Thompson,Erik Ingelsson,Danish Saleheen,Danish Saleheen,Jeanette Erdmann,Benjamin A. Goldstein,Kathleen Stirrups,Inke R. König,Jean-Baptiste Cazier,Åsa Johansson,Alistair S. Hall,Jong-Young Lee,Cristen J. Willer,John C. Chambers,Tõnu Esko,Lasse Folkersen,Anuj Goel,Elin Grundberg,Aki S. Havulinna,Weang K. Ho,Jemma C. Hopewell,Niclas Eriksson,Marcus E. Kleber,Kati Kristiansson,Per Lundmark,Leo-Pekka Lyytikäinen,Suzanne Rafelt,Dmitry Shungin,Dmitry Shungin,Rona J. Strawbridge,Gudmar Thorleifsson,Emmi Tikkanen,Emmi Tikkanen,Natalie R. van Zuydam,Benjamin F. Voight,Lindsay L. Waite,Weihua Zhang,Andreas Ziegler,Devin Absher,David Altshuler,David Altshuler,Anthony J. Balmforth,Inês Barroso,Inês Barroso,Peter S. Braund,Peter S. Braund,Christof Burgdorf,Simone Claudi-Boehm,David G. Cox,Maria Dimitriou,Ron Do,Ron Do,Alex S. F. Doney,Nour Eddine El Mokhtari,Per Eriksson,Krista Fischer,Pierre Fontanillas,Anders Franco-Cereceda,Bruna Gigante,Leif Groop,Stefan Gustafsson,Jorg Hager,Göran Hallmans,Bok Ghee Han,Sarah E. Hunt,Hyun Min Kang,Thomas Illig,Thorsten Kessler,Joshua W. Knowles,Genovefa Kolovou,Johanna Kuusisto,Claudia Langenberg,Cordelia Langford,Karin Leander,Marja-Liisa Lokki,Anders Lundmark,Mark I. McCarthy,Christa Meisinger,Olle Melander,Evelin Mihailov,Seraya Maouche,Andrew D. Morris,Martina Müller-Nurasyid,Kjell Nikus,John F. Peden,N. William Rayner,Asif Rasheed,Silke Rosinger,Diana Rubin,Moritz P. Rumpf,Arne Schäfer,Mohan U. Sivananthan,Ci Song,Alexandre F.R. Stewart,Sian Tsung Tan,Gudmundur Thorgeirsson,C. Ellen van der Schoot,Peter Wagner,Peter Wagner,George A. Wells,Philipp S. Wild,Tsun-Po Yang,Philippe Amouyel,Dominique Arveiler,Hanneke Basart,Michael Boehnke,Eric Boerwinkle,Paolo Brambilla,François Cambien,Adrienne Cupples,Adrienne Cupples,Ulf de Faire,Abbas Dehghan,Patrick Diemert,Stephen E. Epstein,Alun Evans,Marco M Ferrario,Jean Ferrières,Dominique Gauguier,Dominique Gauguier,Alan S. Go,Alison H. Goodall,Alison H. Goodall,Villi Gudnason,Stanley L. Hazen,Hilma Holm,Carlos Iribarren,Yangsoo Jang,Mika Kähönen,Frank Kee,Hyo-Soo Kim,Norman Klopp,Wolfgang Koenig,Wolfgang Kratzer,Kari Kuulasmaa,Markku Laakso,Reijo Laaksonen,Jiyoung Lee,Lars Lind,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Sarah Parish,Jeong E. Park,Nancy L. Pedersen,Annette Peters,Thomas Quertermous,Daniel J. Rader,Veikko Salomaa,Eric E. Schadt,Svati H. Shah,Juha Sinisalo,Klaus Stark,Kari Stefansson,Kari Stefansson,David-Alexandre Trégouët,Jarmo Virtamo,Lars Wallentin,Nicholas J. Wareham,Martina E. Zimmermann,Markku S. Nieminen,Christian Hengstenberg,Manjinder S. Sandhu,Manjinder S. Sandhu,Tomi Pastinen,Ann-Christine Syvänen,G. Kees Hovingh,George Dedoussis,Paul W. Franks,Paul W. Franks,Paul W. Franks,Terho Lehtimäki,Andres Metspalu,Pierre Zalloua,Agneta Siegbahn,Stefan Schreiber,Samuli Ripatti,Samuli Ripatti,Stefan Blankenberg,Markus Perola,Robert Clarke,Bernhard O. Boehm,Christopher J. O'Donnell,Muredach P. Reilly,Winfried März,Winfried März,Rory Collins,Sekar Kathiresan,Sekar Kathiresan,Anders Hamsten,Jaspal S. Kooner,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,John Danesh,Colin N. A. Palmer,Robert Roberts,Hugh Watkins,Heribert Schunkert,Nilesh J. Samani,Nilesh J. Samani +204 more
TL;DR: An association analysis in CAD cases and controls identifies 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants strongly associated with CAD at a 5% false discovery rate (FDR).
Journal ArticleDOI
Marrow-Derived Stromal Cells Express Genes Encoding a Broad Spectrum of Arteriogenic Cytokines and Promote In Vitro and In Vivo Arteriogenesis Through Paracrine Mechanisms
Tim Kinnaird,Eugenio Stabile,Mary-Susan Burnett,Cheol Whan Lee,S. Barr,Shmuel Fuchs,Stephen E. Epstein +6 more
TL;DR: In this article, the full spectrum of cytokine genes expressed by marrow stromal cells (MSCs) were characterized using Affymetrix GeneChips representing 12 000 genes.