Stephen H. Wright

TL;DR: Overall, it is advised that the timing of transporter investigations should be driven by efficacy, safety and clinical trial enrolment questions, as well as a need for further understanding of the absorption, distribution, metabolism and excretion properties of the drug molecule, and information required for drug labelling.

TL;DR: Recent work on attempts to integrate information concerning the activity of cloned transporters in heterologous expression systems to that observed in studies of physiologically intact renal systems is examined.

TL;DR: The intention is to provide students a general view of the quantitative relationship that exists between 1) transmembrane gradients for K(+ and Na(+) and 2) the relative channel-mediated permeability of the membrane to these ions.

TL;DR: It is increasingly apparent that basolateral and luminal OC transport reflects the concerted activity of a suite of separate transport processes arranged in parallel in each pole of proximal tubule cells.

TL;DR: Results indicate how a combination of computational and in vitro approaches may yield insight into the binding affinity of transporters and may be applicable to predicting these properties for new therapeutics.