S
Stephen J. Haggarty
Researcher at Harvard University
Publications - 227
Citations - 28584
Stephen J. Haggarty is an academic researcher from Harvard University. The author has contributed to research in topics: Induced pluripotent stem cell & Histone deacetylase. The author has an hindex of 60, co-authored 216 publications receiving 23970 citations. Previous affiliations of Stephen J. Haggarty include Massachusetts Institute of Technology & National Institutes of Health.
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Journal ArticleDOI
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
Justin Lamb,Emily D. Crawford,David Peck,Joshua W. Modell,Irene C. Blat,Matthew J. Wrobel,Jim Lerner,Jean Philippe Brunet,Aravind Subramanian,Kenneth N. Ross,Michael Reich,Haley Hieronymus,Haley Hieronymus,Guo Wei,Guo Wei,Scott A. Armstrong,Scott A. Armstrong,Stephen J. Haggarty,Stephen J. Haggarty,Paul A. Clemons,Ru Wei,Steven A. Carr,Eric S. Lander,Eric S. Lander,Todd R. Golub +24 more
TL;DR: The first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules is created, and it is demonstrated that this “Connectivity Map” resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs.
Journal ArticleDOI
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Aravind Subramanian,Rajiv Narayan,Steven M. Corsello,Steven M. Corsello,David Peck,Ted Natoli,Xiaodong Lu,Joshua Gould,John F. Davis,Andrew A. Tubelli,Jacob K. Asiedu,David L. Lahr,Jodi E. Hirschman,Zihan Liu,Melanie Donahue,Bina Julian,Mariya Khan,David Wadden,Ian Smith,Daniel D. Lam,Arthur Liberzon,Courtney Toder,Mukta Bagul,Marek Orzechowski,Oana M. Enache,Federica Piccioni,Sarah A. Johnson,Nicholas J. Lyons,Alice H. Berger,Alice H. Berger,Alykhan F. Shamji,Angela N. Brooks,Angela N. Brooks,Anita Vrcic,Corey Flynn,Jacqueline Rosains,David Y. Takeda,David Y. Takeda,Roger Hu,Desiree Davison,Justin Lamb,Kristin Ardlie,Larson Hogstrom,Peyton Greenside,Nathanael S. Gray,Nathanael S. Gray,Paul A. Clemons,Serena J. Silver,Xiaoyun Wu,Wen-Ning Zhao,Wen-Ning Zhao,Willis Read-Button,Xiaohua Wu,Stephen J. Haggarty,Stephen J. Haggarty,Lucienne Ronco,Jesse S. Boehm,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber,John G. Doench,Joshua A. Bittker,David E. Root,Bang Wong,Todd R. Golub +64 more
TL;DR: The expanded CMap is reported, made possible by a new, low-cost, high-throughput reduced representation expression profiling method that is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.
Journal ArticleDOI
Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen
Thomas U. Mayer,Tarun M. Kapoor,Stephen J. Haggarty,Stephen J. Haggarty,Randall W. King,Stuart L. Schreiber,Stuart L. Schreiber,Timothy J. Mitchison +7 more
TL;DR: In vitro, monastrol specifically inhibited the motility of the mitotic kinesin Eg5, a motor protein required for spindle bipolarity, and will therefore be a particularly useful tool for studying mitotic mechanisms.
Journal ArticleDOI
HDAC2 negatively regulates memory formation and synaptic plasticity
Ji-Song Guan,Stephen J. Haggarty,Emanuela Giacometti,Jan Hermen Dannenberg,Jan Hermen Dannenberg,Nadine F. Joseph,Nadine F. Joseph,Jun Gao,Thomas J.F. Nieland,Ying Zhou,X. L. Wang,Ralph Mazitschek,James E. Bradner,Ronald A. DePinho,Rudolf Jaenisch,Li-Huei Tsai,Li-Huei Tsai +16 more
TL;DR: It is suggested that HDAC2 functions in modulating synaptic plasticity and long-lasting changes of neural circuits, which in turn negatively regulates learning and memory.
Journal ArticleDOI
A polygenic burden of rare disruptive mutations in schizophrenia
Shaun Purcell,Jennifer L. Moran,Menachem Fromer,Douglas M. Ruderfer,Nadia Solovieff,Panos Roussos,Colm O'Dushlaine,Kimberly Chambert,Sarah E. Bergen,Anna K. Kähler,Laramie E. Duncan,Eli A. Stahl,Giulio Genovese,Esperanza Fernández,Mark O. Collins,Noboru H. Komiyama,Jyoti S. Choudhary,Patrik K. E. Magnusson,Eric Banks,Khalid Shakir,Kiran V. Garimella,Timothy Fennell,Mark A. DePristo,Seth G. N. Grant,Stephen J. Haggarty,Stacey Gabriel,Edward M. Scolnick,Eric S. Lander,Christina M. Hultman,Patrick F. Sullivan,Steven A. McCarroll,Pamela Sklar +31 more
TL;DR: In this article, the exome sequences of 2,536 schizophrenia cases and 2,543 controls were analyzed and the authors demonstrated a polygenic burden primarily arising from rare (less than 1 in 10,000), disruptive mutations distributed across many genes.