S
Stephen J. Meltzer
Researcher at Johns Hopkins University School of Medicine
Publications - 289
Citations - 26265
Stephen J. Meltzer is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Cancer & DNA methylation. The author has an hindex of 82, co-authored 276 publications receiving 24789 citations. Previous affiliations of Stephen J. Meltzer include University of Maryland Marlene and Stewart Greenebaum Cancer Center & University of Maryland, Baltimore.
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Journal Article
A National Cancer Institute Workshop on Microsatellite Instability for Cancer Detection and Familial Predisposition: Development of International Criteria for the Determination of Microsatellite Instability in Colorectal Cancer
C. Richard Boland,Stephen N. Thibodeau,Stanley R. Hamilton,David Sidransky,James R. Eshleman,Randall W. Burt,Stephen J. Meltzer,Miguel A. Rodriguez-Bigas,Riccardo Fodde,G. Nadia Ranzani,Sudhir Srivastava +10 more
TL;DR: The spectrum of microsatellite alterations in noncolonic tumors was reviewed, and it was concluded that the above recommendations apply only to colorectal neoplasms.
Journal ArticleDOI
6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity.
TL;DR: The data, showing a low incidence of toxicity in 396 patients, coupled with the previously demonstrated efficacy of 6-mercaptopurine in the treatment ofinflammatory bowel disease, indicate that the drug is a reasonable alternative in the management of patients with intractable inflammatory bowel disease.
Journal Article
Increased Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in Barrett's Esophagus and Associated Adenocarcinomas
TL;DR: Findings support the hypothesis that iNOS and COX-2 are involved early and often in Barrett's-associated neoplastic progression.
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MicroRNAs and epigenetics.
TL;DR: The present minireview details recent discoveries involving the epigenetics–miRNA regulatory circuit, suggesting possible biological insights into gene‐regulatory mechanisms that may underlie a variety of diseases.
Journal Article
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.
Manel Esteller,Andrew B. Sparks,Minoru Toyota,Montserrat Sanchez-Cespedes,Gabriel Capellá,Miguel A. Peinado,Sara González,Gemma Tarafa,David Sidransky,Stephen J. Meltzer,Stephen B. Baylin,James G. Herman +11 more
TL;DR: It is reported that methylation in the promoter region of this gene constitutes an alternative mechanism for gene inactivation in colon and other tumors of the gastrointestinal tract and underscores the importance of the APC pathway in gastrointestinal tumorigenesis.