S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
Comparative feline genomics: a BAC/PAC contig map of the major histocompatibility complex class II region.
Thomas William Beck,Joan C. Menninger,Ginny Voigt,Kimberly Newmann,Yoko Nishigaki,William G. Nash,Robert M. Stephens,Yu Wang,Pieter J. de Jong,Stephen J. O'Brien,Naoya Yuhki +10 more
TL;DR: Fluorescence in situ hybridization analyses of selected class II PAC clones confirmed that the class II region lies in the pericentromeric region of cat chromosome B2, but apparently unlike the human and mouse MHCs, the domestic cat DRA and DRB genes have undergone multiple duplications and the DQ region has been deleted.
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Estimation of the bottleneck size in Florida panthers
TL;DR: The recent intensive monitoring both before and after the introduction of Texas pumas in 1995 will make the recovery and genetic restoration of Florida panthers a classic study of an endangered species.
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Consistent Effects of TSG101 Genetic Variability on Multiple Outcomes of Exposure to Human Immunodeficiency Virus Type 1
Arman Bashirova,Gabriela Bleiber,Ying Qi,Holli B. Hutcheson,Traci E. Yamashita,Randall C. Johnson,Jie Cheng,Galit Alter,James J. Goedert,Susan Buchbinder,Keith Hoots,David Vlahov,Margaret T May,Frank Maldarelli,Lisa P. Jacobson,Stephen J. O'Brien,Amalio Telenti,Mary Carrington +17 more
TL;DR: The hypothesis that noncoding variation in TSG101 affects the efficiency of TSG 101-mediated release of viral particles from infected cells, thereby altering levels of plasma viral load and subsequent disease progression is raised.
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A rhesus macaque radiation hybrid map and comparative analysis with the human genome
William J. Murphy,Richa Agarwala,Alejandro A. Schäffer,Robert M. Stephens,Clarence Smith,Nicole J. Crumpler,Victor A. David,Stephen J. O'Brien +7 more
TL;DR: Analysis of the breakpoints flanking inverted chromosomal segments and estimation of their duplication divergence dates provide additional evidence implicating segmental duplications as a major mechanism of chromosomal rearrangement in recent primate evolution.
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A New Moderately Repetitive DNA Sequence Family of Novel Organization
Neal D. Epstein,Stefan Karlsson,Stephen J. O'Brien,William S. Modi,Austine Davis Moulton,Arthur W. Nienhuis +5 more
TL;DR: A new family of moderately repetitive DNA sequences, unique because of its organization in clustered tandem arrays, its length, its chromosomal location, and its lack of homology to other moderately repetitive sequence families is identified.