S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
Papers
More filters
Journal ArticleDOI
Genetic fingerprinting reflects population differentiation in the California Channel Island fox.
TL;DR: In small populations of genetically isolated mammals, differences among hypervariable restriction-fragment profiles can be used to estimate relative genetic variability and to reconstruct the evolutionary relationships of natural populations.
Journal ArticleDOI
Genome-wide scans for footprints of natural selection
TL;DR: These approaches to identify genome signatures of historic selective pressures on genes and gene regions in other species with emerging genome sequences are reviewed and compared to provide independent verification (or not) of regions found by different methods and using different populations.
Journal ArticleDOI
Reliability, validity, and responsiveness of four knee outcome scales for athletic patients.
Robert G. Marx,Edward C. Jones,Answorth A. Allen,David W. Altchek,Stephen J. O'Brien,Scott A. Rodeo,Riley J. Williams,Russell F. Warren,Thomas L. Wickiewicz +8 more
TL;DR: All four knee-rating scales commonly used for the evaluation of athletic patients satisfied the criteria for reliability, validity, and responsiveness, and all are acceptable for use in clinical research.
Journal ArticleDOI
Genetic Evidence for Two Species of Elephant in Africa
TL;DR: Dart-biopsy samples from 195 free-ranging African elephants in 21 populations were examined for DNA sequence variation in four nuclear genes and showed large genetic distance, multiple genetically fixed nucleotide site differences, morphological and habitat distinctions, and extremely limited hybridization of gene flow support the recognition and conservation management of two African species.
Journal ArticleDOI
The adaptive evolution of the mammalian mitochondrial genome.
Rute R. da Fonseca,Rute R. da Fonseca,Warren E. Johnson,Stephen J. O'Brien,Maria J. Ramos,Agostinho Antunes,Agostinho Antunes +6 more
TL;DR: This study provides insight into the adaptive evolution of the mtDNA genome in mammals and its implications for the molecular mechanism of oxidative phosphorylation, and presents a framework for future experimental characterization of the impact of specific mutations in the function, physiology, and interactions of themtDNA encoded proteins involved in oxidativeosphorylation.