S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
MICA and recovery from hepatitis C virus and hepatitis B virus infections
Peter Karacki,Xiaojiang Gao,Chloe L. Thio,David L. Thomas,David L. Thomas,James J. Goedert,David Vlahov,David Vlahov,Richard A. Kaslow,Steffanie A. Strathdee,Margaret W. Hilgartner,Stephen J. O'Brien,Mary Carrington +12 more
TL;DR: Data provide little support for the hypothesis that differential distribution of MICA alleles substantially affects recovery from HCV and HBV infections.
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Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
Yu Liang,Weizhong Tang,Tiquiang Huang,Yong Gao,Aihua Tan,Xiaobo Yang,Haiying Zhang,Yanling Hu,Xue Qin,Shan Li,Shijun Zhang,Linjian Mo,Zhenjia Liang,Deyi Shi,Zhang Huang,Yingyong Guan,Jicheng Zhou,Cheryl A. Winkler,Stephen J. O'Brien,Jianfeng Xu,Zengnan Mo,Tao Peng +21 more
TL;DR: Zhang et al. as mentioned in this paper investigated the genetic markers associated with elevated serum sCEA level in colorectal cancer (CRC) patients and its clinical implications and found candidate SNPs associated with increased sCEAs in both healthy males and CRC patients.
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Exchanges of short polymorphic DNA segments predating speciation in feline major histocompatibility complex class I genes.
Naoya Yuhki,Stephen J. O'Brien +1 more
TL;DR: The pattern of sequence variation in felids supports the role of the following factors in production and maintenance of MHC variation: gradual spontaneous mutation, selective pressure to conserve certain residues but also to vary in hypervariable regions, notably residues that functionally participate in antigen recognition and presentation.
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Multicohort Genomewide Association Study Reveals a New Signal of Protection Against HIV-1 Acquisition
Sophie Limou,Sophie Limou,Olivier Delaneau,Daniëlle van Manen,Ping An,Efe Sezgin,Sigrid Le Clerc,Cédric Coulonges,Jennifer L. Troyer,Jan H. Veldink,Leonard H. van den Berg,Jean Louis Spadoni,Lieng Taing,Taoufik Labib,Matthieu Montes,Jean François Delfraissy,François Schächter,Stephen J. O'Brien,Susan Buchbinder,Mark L. Van Natta,Douglas A. Jabs,Douglas A. Jabs,Philippe Froguel,Philippe Froguel,Hanneke Schuitemaker,Cheryl A. Winkler,Jean-François Zagury +26 more
TL;DR: First clues point to a potential functional role for a nearby candidate gene, CYP7B1, but this locus warrants further investigation, while strong evidence of association for a common variant with HIV-1 acquisition in populations of European ancestry is provided.
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Long non-coding RNA (lncRNA) and epithelial-mesenchymal transition (EMT) in colorectal cancer: a systematic review.
Stephen J. O'Brien,Campbell Bishop,Jacob Hallion,Casey Fiechter,Katharina M Scheurlen,Mason Paas,James R. Burton,Susan Galandiuk +7 more
TL;DR: In this article, a systematic review of cancer metastasis development in colon cancer is presented, where Epithelial-mesenchymal transition (EMT) is a major process in tumor metastasis.