S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
Papers
More filters
Journal ArticleDOI
Molecular cloning and chromosomal mapping of feline p53 tumor suppressor gene.
Masaru Okuda,Akiko Umeda,Yasunobu Matsumoto,Yasuyuki Momoi,Toshihiro Watari,Ryo Goitsuka,Stephen J. O'Brien,Hajime Tsujimoto,Atsuhiko Hasegawa +8 more
TL;DR: Feline p53 cDNA was molecularly cloned by PCR amplifications using primers based on the sequences conserved among several species and was assigned to feline chromosome E1, useful for determining the role of the p53 tumor suppressor gene in feline tumors.
Journal ArticleDOI
Stromal cell-derived factor-1 genotype, coreceptor tropism, and HIV type 1 disease progression.
Eric S. Daar,Henry Lynn,Sharyne Donfield,Alice Lail,Stephen J. O'Brien,Wei Huang,Cheryl A. Winkler +6 more
TL;DR: The increased frequency of X4-tropic viruses in subjects carrying the SDF1-3'A allele may explain the observed adverse effect that this allele has on the natural history of HIV-1 disease.
Journal Article
Feline immunodeficiency virus integration in B-cell lymphoma identifies a candidate tumor suppressor gene on human chromosome 15q15
Julia A. Beatty,Anne Terry,Julie Macdonald,Elizabeth Gault,Stanley Cevario,Stephen J. O'Brien,Ewan R. Cameron,James C. Neil +7 more
TL;DR: Observations demonstrate the direct mutagenic potential of the lentiviruses and identify a new candidate tumor suppressor gene.
Journal ArticleDOI
Genetic variation in Sri Lankan leopards
S. Miththapala,S. Miththapala,John Seidensticker,Lyndsay Phillips,K. L. Goodrowe,S. B. U. Fernando,Lisa Forman,Stephen J. O'Brien +7 more
TL;DR: The overall results revealed a detectable decrease in genetic variability compared with a previous study of captive leopards from mainland origins, and no significant differences in polymorphic loci were observed between the leopard subspecies examined.
Journal ArticleDOI
Comparative genomics: The next generation
TL;DR: Strategies for combining the advantages of Type I and Type II locus markers are presented with emphasis on application of these concepts to the construction of a gene map of the domestic cat.