S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
Using Mutual Information to Measure the Impact of Multiple Genetic Factors on Aids
TL;DR: It is shown that 13 genetic factors can cumulatively explain 9% of slow progression to AIDS, an effect comparable to the effect of smoking on lung cancer.
Journal ArticleDOI
Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species
Anastasia A. Proskuryakova,Anastasia I. Kulemzina,Polina L. Perelman,Dmitry V. Yudkin,Natalya A. Lemskaya,Innokentii M. Okhlopkov,Egor V. Kirillin,Marta Farré,Marta Farré,Denis M. Larkin,Melody E. Roelke-Parker,Stephen J. O'Brien,Stephen J. O'Brien,Mitchell Bush,Alexander S. Graphodatsky +14 more
TL;DR: A detailed chromosome map of musk ox (Ovibos moschatus), a relic species originating from Pleistocene megafauna, is built with dromedary and human probes using chromosome painting to trace chromosomal rearrangements during Bovidae evolution by comparing species already studied by chromosome painting.
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Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia.
Ping An,Rongling Li,Ji Ming Wang,Teizo Yoshimura,Munehisa Takahashi,Ram Samudralal,Stephen J. O'Brien,John P. Phair,James J. Goedert,Gregory D. Kirk,Jennifer L. Troyer,Efe Sezgin,Susan Buchbinder,Sharyne M. Donfield,George W. Nelson,Cheryl A. Winkler +15 more
TL;DR: Considering the newly defined role of CCRL2 in lung dendritic cell trafficking, this atypical chemokine receptor may affect PCP through immune regulation and inducing inflammation.
Journal ArticleDOI
Pyoderma Gangrenosum in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Vanessa States,Stephen J. O'Brien,Jayesh P. Rai,Henry Roberts,Mason Paas,Kayla Feagins,Evangeline J Pierce,Richard N. Baumgartner,Susan Galandiuk +8 more
TL;DR: This meta-analysis confirms an association between PG and female gender, Crohn’s disease, erythema nodosum, and ocular EIM that have been described in smaller studies.
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Comparative analysis of malate dehydrogenases of Drosophila melanogaster.
TL;DR: The malate dehydrogenases of D. melanogaster have been resolved into a cytoplasmic form (cMDH) and a mitochondrial matrix form (mMDH), and both enzymes exhibit markedly similar properties with respect to catalytic activity, pH optima, pH optimum shift in response to different ionic environments, and molecular weight as determined by sucrose density gradient sedimentation.