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Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
The Genome-Wide Analysis of Carcinoembryonic Antigen Signaling by Colorectal Cancer Cells Using RNA Sequencing
Olga Bajenova,Anna Gorbunova,Igor Evsyukov,Michael Rayko,Svetlana Gapon,Ekaterina Bozhokina,Alexander A. Shishkin,Stephen J. O'Brien,Stephen J. O'Brien +8 more
TL;DR: The results suggest that CEA production by colorectal cancer cells triggers coloreCTal cancer progression by inducing the epithelial- mesenchymal transition, increasing tumor cell invasiveness into the surrounding tissues and suppressing stress and apoptotic signaling.
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Intestinal Expression of Fas and Fas Ligand Is Upregulated by Bacterial Signaling through TLR4 and TLR5, with Activation of Fas Modulating Intestinal TLR-Mediated Inflammation
Philana Fernandes,Charlotte O'Donnell,Caitriona Lyons,Jonathan Keane,Tim Regan,Stephen J. O'Brien,Padraic G. Fallon,Elizabeth Brint,Aileen Houston +8 more
TL;DR: It is demonstrated that extensive cross-talk in IECs occurs between the Fas and TLR signaling pathways, with the FasL/Fas system playing a role in TLR-mediated inflammatory responses in the intestine.
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The contact neodymium-yttrium aluminum garnet laser. A new approach to arthroscopic laser surgery.
Stephen J. O'Brien,D V Miller +1 more
TL;DR: The contact Nd-YAG laser has advantages over both scalpel and electrocautery with regard to its effects on articular cartilage and the meniscus and represents the possible beginning of a new era for application of laser energy in arthroscopy.
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Continued decline in genetic diversity among wild cheetahs (Acinonyx jubatus) without further loss of semen quality
Kimberly A. Terrell,Kimberly A. Terrell,Adrienne E. Crosier,David E. Wildt,Stephen J. O'Brien,Stephen J. O'Brien,Nicola M. Anthony,Laurie Marker,Warren E. Johnson +8 more
TL;DR: Data suggest a more complex relationship between inbreeding and male cheetah reproductive traits than previously appreciated, and that genetic diversity has decreased in the wild, but not captive, population.
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Prevalence and Estimated Incidence of Blood-Borne Viral Pathogen Infection in Organ and Tissue Donors from Northern Alberta
G. Zahariadis,Sabrina S. Plitt,Stephen J. O'Brien,Stephen J. O'Brien,Q. L. Yi,W. Fan,Jutta K. Preiksaitis +6 more
TL;DR: To determine the potential safety benefit of introducing nucleic acid testing (NAT) in tissue and organ donors, the risk of virus transmission was examined in a Canadian population.