S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
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Visualization, sharing and analysis of large data sets
TL;DR: In this paper, the authors describe systems and methods for visualization, sharing and analysis of large data sets, where the input data set includes data that can be classified in classification dimensions wherein a first classification dimension is a linear ordering of data entries and a second classification dimension represents analysis criteria, traits of the data entries, or aspects of the entries.
Journal ArticleDOI
Preoperative Opioid Prescription Is Associated With Major Complications in Patients With Crohn's Disease Undergoing Elective Ileocolic Resection.
Stephen J. O'Brien,Ryan C Chen,Vincent Stephen,Jeffrey Jorden,Russell W. Farmer,Stephen Manek,Miranda N. Schmidt,Jianmin Pan,Shesh N. Rai,Susan Galandiuk +9 more
TL;DR: Preoperative opioid prescription was a significant risk factor for adverse outcomes in patients with Crohn’s disease undergoing elective ileocolic resection, and could not assess nonprescribed opioid use.
Journal ArticleDOI
halSynteny: a fast, easy-to-use conserved synteny block construction method for multiple whole-genome alignments
Ksenia Krasheninnikova,Ksenia Krasheninnikova,Mark Diekhans,Joel Armstrong,Aleksei Dievskii,Benedict Paten,Stephen J. O'Brien,Stephen J. O'Brien +7 more
TL;DR: HalSynteny enables an accurate and rapid identification of synteny in multiple full-genome alignments and performs efficient processing of pairwise alignment blocks for any pair of genomes in the alignment.
Journal ArticleDOI
Temporal expression of circulating miRNA after severe injury
Norman J. Galbraith,Stephen J. O'Brien,Samuel Walker,Sarah A. Gardner,Hiram C. Polk,Stephen L. Barnes +5 more
TL;DR: In this article, the temporal and differential expression of previously identified dysregulated micro-RNAs in patients with severe injury was examined, and miR-106a was downregulated at all time points compared with healthy controls.
Posted ContentDOI
Mountain lion genomes provide insights into genetic rescue of inbred populations
Saremi Nf,Megan A. Supple,Ashley Byrne,James A. Cahill,Luiz Lehmann Coutinho,Love Dalén,Henrique V. Figueiró,Warren E. Johnson,Heather J. Milne,Stephen J. O'Brien,Brendan O'Connell,Brendan O'Connell,David P. Onorato,Seth P. D. Riley,Jeffrey A. Sikich,Daniel R. Stahler,Villela Pms,Christopher Vollmers,Robert K. Wayne,Eduardo Eizirik,Russell Corbett-Detig,Richard E. Green,Christopher C. Wilmers,Beth Shapiro +23 more
TL;DR: A high-quality mountain lion genome is assembled and a panel of resequenced individuals from across their geographic range is analyzed, finding strong geographical structure and signatures of severe inbreeding in all North American populations.