S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
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Evolution of mammalian genome organization inferred from comparative gene mapping
TL;DR: Comparative genome analyses, including chromosome painting in over 40 diverse mammalian species, ordered gene maps from several representatives of different mammalian and vertebrate orders, and large-scale sequencing of the human and mouse genomes are beginning to provide insight into the rates and patterns of chromosomal evolution on a whole-genome scale.
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Pattern and timing of diversification of the mammalian order Carnivora inferred from multiple nuclear gene sequences.
Eduardo Eizirik,William J. Murphy,Klaus-Peter Koepfli,Warren E. Johnson,Jerry W. Dragoo,Robert K. Wayne,Stephen J. O'Brien +6 more
TL;DR: This study investigated the phylogenetic relationships among carnivoran families, and performed molecular dating analyses of the inferred nodes, leading to consistent and robust resolution of all supra-familial nodes in the carnivoran tree.
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Evolutionary conservation of ten microsatellite loci in four species of Felidae.
TL;DR: The isolation, characterization, and PCR amplification of 10 microsatellite loci from the domestic cat, Felis catus, are described and abundant polymorphism in puma, lion, cheetah, and domestic cat is demonstrated.
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Phylogenetics, genome diversity and origin of modern leopard, Panthera pardus
Olga Uphyrkina,Warren E. Johnson,Howard B. Quigley,Dale G. Miquelle,Laurie Marker,M. Bush,Stephen J. O'Brien +6 more
TL;DR: Combined phylogeographic and population diversity estimates support an origin for modern leopard lineages 470 000–825 000 years ago in Africa followed by their migration into and across Asia more recently (170 000–300 thousands years ago).
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Modulating influence on HIV/AIDS by interacting RANTES gene variants.
Ping An,George W. Nelson,Lihua Wang,Sharyne Donfield,James J. Goedert,John P. Phair,David Vlahov,Susan Buchbinder,William L. Farrar,William S. Modi,Stephen J. O'Brien,Cheryl A. Winkler +11 more
TL;DR: The diminished transcription of RANTES afforded by the In1.1C regulatory allele is consistent with increased HIV-1 spread in vivo, leading to accelerated progression to AIDS.