S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
Light whole genome sequence for SNP discovery across domestic cat breeds
James C. Mullikin,Nancy F. Hansen,Lei Shen,Heather Ebling,William F. Donahue,Wei Tao,David J. Saranga,Adrianne Brand,Marc J. Rubenfield,Alice C. Young,Pedro Cruz,Carlos A. Driscoll,Victor A. David,Samer Al-Murrani,Mary F. Locniskar,Mitchell S. Abrahamsen,Stephen J. O'Brien,Douglas Smith,Jeffrey Brockman +18 more
TL;DR: These data provide a large collection of mapped feline SNPs across the cat genome that will allow for the development of SNP genotyping platforms for mapping feline diseases.
Journal Article
Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines.
Michael D. Miller,Stephen D. Wilson,Martin E. Dorf,Hector N. Seuanez,Stephen J. O'Brien,Michael S. Krangel +5 more
TL;DR: The genomic organization is essentially identical to that found in the genes encoding the structurally similar proteins TCA-3, hJE/MCP-1, and mJE, strengthening the hypothesis that these genes are evolutionarily related.
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An analysis of tumor necrosis factor α gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection
Chloe L. Thio,James J. Goedert,Timothy Mosbruger,David Vlahov,Steffanie A. Strathdee,Stephen J. O'Brien,Jacquie Astemborski,David L. Thomas +7 more
TL;DR: Nine TNF SNPs were typed in a cohort of individuals with well-defined HCV outcomes and the common wild-type haplotype −863C/−308G was associated with viral persistence in black subjects, independent of linkage with human leukocyte antigen (HLA) alleles.
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Dispermic origin and clinical outcome of three complete hydatidiform moles with 46,XY karyotype☆
TL;DR: Levels of human chorionic gonadotropin decreased to normal spontaneously within a short time, indicating a benign course in these three cases of complete, classic hydatidiform mole with a 46,XY karyotype.
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THE α-GLYCEROPHOSPHATE CYCLE IN DROSOPHILA MELANOGASTER IV. Metabolic, Ultrastructural, and Adaptive Consequences of αGpdh-1 "Null" Mutations
TL;DR: There was a premature deterioration and atrophy of the ultrastructural integrity of flight muscle sarcosomes observed by electron microscopy in the "null" mutants, accompanied by premature mortality of the mutant heterozygotes.