Stephen L. Buchwald

TL;DR: An overview of the use and impact of dialkylbiarylphosphine ligands in the Suzuki-Miyaura cross-coupling reaction and the utility of these ligands has been successfully demonstrated in a wide number of synthetic applications, including industrially relevant processes.

TL;DR: The application ofadium-catalyzed amination reactions of aryl halides in C-N cross-coupling reactions in the synthesis of heterocycles and pharmaceuticals, in materials science, and in natural product synthesis is discussed.

TL;DR: An overview of Pd-catalyzed N-arylation reactions found in both basic and applied chemical research from 2008 to the present is provided.

TL;DR: Structural studies of various 1.Pd complexes are presented along with computational data that help elucidate the efficacy that 1 imparts on Suzuki-Miyaura coupling processes, and a comparison of the reactions is presented that is informative in determining the relative importance of ligand bulk and electron-donating ability in the high activity of catalysts derived from ligands of this type.