Stephen Muggleton

Bio: Stephen Muggleton is an academic researcher from Imperial College London. The author has contributed to research in topics: Inductive logic programming & PROGOL. The author has an hindex of 46, co-authored 242 publications receiving 11680 citations. Previous affiliations of Stephen Muggleton include Astellas Pharma & University of London.

Inductive Logic Programming : Theory and Methods

Abstract: Inductive Logic Programming (ILP) is a new discipline which investigates the inductive construction of first-order clausal theories from examples and background knowledge. We survey the most important theories and methods of this new field. First, various problem specifications of ILP are formalized in semantic settings for ILP, yielding a “model-theory” for ILP. Second, a generic ILP algorithm is presented. Third, the inference rules and corresponding operators used in ILP are presented, resulting in a “proof-theory” for ILP. Fourth, since inductive inference does not produce statements which are assured to follow from what is given, inductive inferences require an alternative form of justification. This can take the form of either probabilistic support or logical constraints on the hypothesis language. Information compression techniques used within ILP are presented within a unifying Bayesian approach to confirmation and corroboration of hypotheses. Also, different ways to constrain the hypothesis language or specify the declarative bias are presented. Fifth, some advanced topics in ILP are addressed. These include aspects of computational learning theory as applied to ILP, and the issue of predicate invention. Finally, we survey some applications and implementations of ILP. ILP applications fall under two different categories: first, scientific discovery and knowledge acquisition, and second, programming assistants.

Inverse entailment and PROGOL

Abstract: This paper firstly provides a re-appraisal of the development of techniques for inverting deduction, secondly introduces Mode-Directed Inverse Entailment (MDIE) as a generalisation and enhancement of previous approaches and thirdly describes an implementation of MDIE in the Progol system. Progol is implemented in C and available by anonymous ftp. The re-assessment of previous techniques in terms of inverse implication leads to new results for learning from positive data and inverting implication between pairs of clauses.

Efficient Induction of Logic Programs

Abstract: Recently there has been increasing interest in systems which induce rst order logic programs from examples. However, many diiculties need to be overcome. Well-known algorithms fail to discover correct logical descriptions for large classes of interesting predicates , due either to the intractability of search or overly strong limitations applied to the hypothesis space. In contrast, search is avoided within Plotkin's framework of relative least general generalisation (rlgg). It is replaced by the process of constructing a unique clause which covers a set of examples relative to given background knowledge. However, such a clause can in the worst case contain innnitely many literals, or at best grow exponentially with the number of examples involved. In this paper we introduce the concept of h-easy rlgg clauses and show that they have nite length. We also prove that the length of a certain class of \determinate" rlgg is bounded by a polynomial function of certain features of the background knowledge. This function is independent of the number of examples used to construct them. An existing implementation called GOLEM is shown to be capable of inducing many interesting logic programs which have not been demonstrated to be learnable using other algorithms.

Functional genomic hypothesis generation and experimentation by a robot scientist

Abstract: The question of whether it is possible to automate the scientific process is of both great theoretical interest and increasing practical importance because, in many scientific areas, data are being generated much faster than they can be effectively analysed. We describe a physically implemented robotic system that applies techniques from artificial intelligence to carry out cycles of scientific experimentation. The system automatically originates hypotheses to explain observations, devises experiments to test these hypotheses, physically runs the experiments using a laboratory robot, interprets the results to falsify hypotheses inconsistent with the data, and then repeats the cycle. Here we apply the system to the determination of gene function using deletion mutants of yeast (Saccharomyces cerevisiae) and auxotrophic growth experiments. We built and tested a detailed logical model (involving genes, proteins and metabolites) of the aromatic amino acid synthesis pathway. In biological experiments that automatically reconstruct parts of this model, we show that an intelligent experiment selection strategy is competitive with human performance and significantly outperforms, with a cost decrease of 3-fold and 100-fold (respectively), both cheapest and random-experiment selection.

Machine invention of first order predicates by inverting resolution

Abstract: It has often been noted that the performance of existing learning systems is strongly biased by the vocabulary provided in the problem description language. An ideal system should be capable of overcoming this restriction by defining its own vocabulary. Such a system would be less reliant on the teacher's ingenuity in supplying an appropriate problem representation. For this purpose we present a mechanism for automatically inventing and generalising first-order Horn clause predicates. The method is based on inverting the mechanism of resolution. The approach has its roots in the Duce system for induction of propositional Horn clauses. We have implemented the new mechanism in a system called CIGOL. CIGOL uses incremental induction to augment incomplete clausal theories. A single, uniform knowledge representation allows existing clauses to be used as background knowledge in the construction of new predicates. Given examples of a high-level predicate CIGOL generates related sub-concepts which it then asks its human teacher to name. Generalisations of predicates are tested by asking questions of the human teacher. CIGOL generates new concepts and generalisations with a preference for simplicity. We illustrate the operation of CIGOL by way of various sessions in which auxiliary predicates are automatically introduced and generalised.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

The Design and Analysis of Experiments

Abstract: THE DESIGN AND ANALYSIS OF EXPERIMENTS. By Oscar Kempthorne. New York, John Wiley and Sons, Inc., 1952. 631 pp. $8.50. This book by a teacher of statistics (as well as a consultant for \"experimenters\") is a comprehensive study of the philosophical background for the statistical design of experiment. It is necessary to have some facility with algebraic notation and manipulation to be able to use the volume intelligently. The problems are presented from the theoretical point of view, without such practical examples as would be helpful for those not acquainted with mathematics. The mathematical justification for the techniques is given. As a somewhat advanced treatment of the design and analysis of experiments, this volume will be interesting and helpful for many who approach statistics theoretically as well as practically. With emphasis on the \"why,\" and with description given broadly, the author relates the subject matter to the general theory of statistics and to the general problem of experimental inference. MARGARET J. ROBERTSON

Machine learning

Abstract: Machine Learning is the study of methods for programming computers to learn. Computers are applied to a wide range of tasks, and for most of these it is relatively easy for programmers to design and implement the necessary software. However, there are many tasks for which this is difficult or impossible. These can be divided into four general categories. First, there are problems for which there exist no human experts. For example, in modern automated manufacturing facilities, there is a need to predict machine failures before they occur by analyzing sensor readings. Because the machines are new, there are no human experts who can be interviewed by a programmer to provide the knowledge necessary to build a computer system. A machine learning system can study recorded data and subsequent machine failures and learn prediction rules. Second, there are problems where human experts exist, but where they are unable to explain their expertise. This is the case in many perceptual tasks, such as speech recognition, hand-writing recognition, and natural language understanding. Virtually all humans exhibit expert-level abilities on these tasks, but none of them can describe the detailed steps that they follow as they perform them. Fortunately, humans can provide machines with examples of the inputs and correct outputs for these tasks, so machine learning algorithms can learn to map the inputs to the outputs. Third, there are problems where phenomena are changing rapidly. In finance, for example, people would like to predict the future behavior of the stock market, of consumer purchases, or of exchange rates. These behaviors change frequently, so that even if a programmer could construct a good predictive computer program, it would need to be rewritten frequently. A learning program can relieve the programmer of this burden by constantly modifying and tuning a set of learned prediction rules. Fourth, there are applications that need to be customized for each computer user separately. Consider, for example, a program to filter unwanted electronic mail messages. Different users will need different filters. It is unreasonable to expect each user to program his or her own rules, and it is infeasible to provide every user with a software engineer to keep the rules up-to-date. A machine learning system can learn which mail messages the user rejects and maintain the filtering rules automatically. Machine learning addresses many of the same research questions as the fields of statistics, data mining, and psychology, but with differences of emphasis. Statistics focuses on understanding the phenomena that have generated the data, often with the goal of testing different hypotheses about those phenomena. Data mining seeks to find patterns in the data that are understandable by people. Psychological studies of human learning aspire to understand the mechanisms underlying the various learning behaviors exhibited by people (concept learning, skill acquisition, strategy change, etc.).

Fast algorithms for mining association rules

Abstract: We consider the problem of discovering association rules between items in a large database of sales transactions. We present two new algorithms for solving thii problem that are fundamentally different from the known algorithms. Empirical evaluation shows that these algorithms outperform the known algorithms by factors ranging from three for small problems to more than an order of magnitude for large problems. We also show how the best features of the two proposed algorithms can be combined into a hybrid algorithm, called AprioriHybrid. Scale-up experiments show that AprioriHybrid scales linearly with the number of transactions. AprioriHybrid also has excellent scale-up properties with respect to the transaction size and the number of items in the database.