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Stephen N. Hartland
Researcher at University of Edinburgh
Publications - 6
Citations - 1390
Stephen N. Hartland is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Fibrosis & Hepatic stellate cell. The author has an hindex of 6, co-authored 6 publications receiving 1167 citations. Previous affiliations of Stephen N. Hartland include Medical Research Council.
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Journal ArticleDOI
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
Prakash Ramachandran,Antonella Pellicoro,Madeleine A. Vernon,Luke Boulter,Rebecca L. Aucott,Aysha Ali,Stephen N. Hartland,Victoria K. Snowdon,Andrea Cappon,Timothy T. Gordon-Walker,Mike J. Williams,Donald R. Dunbar,Jonathan R. Manning,Nico van Rooijen,Jonathan A. Fallowfield,Stuart J. Forbes,John P. Iredale +16 more
TL;DR: The restorative macrophage phenotype was recapitulated in vitro by the phagocytosis of cellular debris with associated activation of the ERK signaling cascade, offering a therapeutic strategy to this orphan pathological process.
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Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function.
James Thomas,Caroline Pope,Davina Wojtacha,Andrew Robson,Timothy T. Gordon-Walker,Stephen N. Hartland,Prakash Ramachandran,Marielle Van Deemter,David A. Hume,John P. Iredale,Stuart J. Forbes +10 more
TL;DR: The benefits from this single, defined macrophage type suggest clinical potential and improves clinically relevant parameters in experimental chronic liver injury.
Journal ArticleDOI
Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis
Antonella Pellicoro,Rebecca L. Aucott,Prakash Ramachandran,Andrew Robson,Jonathan A. Fallowfield,Victoria K. Snowdon,Stephen N. Hartland,Madeleine A. Vernon,Jeremy S. Duffield,R. Christopher Benyon,Stuart J. Forbes,John P. Iredale +11 more
TL;DR: Elastin is regulated at the level of degradation during liver fibrosis, and the role of the paradigm elastase macrophage metalloelastase (MMP‐12) in its turnover during fibrosis is defined.
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p75 Neurotrophin receptor signaling regulates hepatic myofibroblast proliferation and apoptosis in recovery from rodent liver fibrosis.
Timothy J. Kendall,Timothy J. Kendall,Selina Hennedige,Rebecca L. Aucott,Stephen N. Hartland,Madeleine A. Vernon,R. Christopher Benyon,John P. Iredale +7 more
TL;DR: The data suggest that cleavage of proNGF by MMP7 during the early phase of recovery from liver fibrosis alters the pro/mature NGF balance to facilitate hepatic myofibroblast loss.
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Active matrix metalloproteinase‐2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N‐cadherin
Stephen N. Hartland,Frank Murphy,Rebecca L. Aucott,Armand Abergel,Xiaoying Zhou,Julian Waung,Nishit Patel,Catherine Bradshaw,Jane E. Collins,Derek A. Mann,R. Christopher Benyon,John P. Iredale +11 more
TL;DR: A potential mechanism whereby MMP activity might induce HSC apoptosis by cleaving N‐cadherin at the cell surface is examined.