Showing papers by "Stephen V. Faraone published in 1985"
142 citations
TL;DR: The two-threshold multifactorial polygenic (MFP) model was applied to blind family study data, collected in a long-term follow-up and family study of major affective disorders, supporting the hypothesis that bipolar and unipolar disorders are, respectively, severe and mild forms of the same disorder.
Abstract: The two-threshold multifactorial polygenic (MFP) model was applied to blind family study data, collected in a long-term follow-up and family study of major affective disorders. This model tested whether bipolar and unipolar disorders are manifestations of the same underlying factors or if they are independently caused disorders. The hypothesis that bipolar and unipolar disorders are, respectively, severe and mild forms of the same disorder was supported. There was little evidence for different familial aetiologies for bipolar and unipolar disorders in our sample.
63 citations
TL;DR: The single major locus (SML) model of Bucher and Elston (1981) was applied to data collected in a long-term follow-up and family study of major effective disorders, finding that it is likely that the existence of a SML will be obscured by genetic heterogeneity.
18 citations