Showing papers by "Stephen V. Faraone published in 1987"

Sex differences in affective disorder: genetic transmission.

Abstract: Epidemiological studies have consistently found women to be at greater risk than men for affective disorders. This sex effect may help clarify genetic transmission and heterogeneity. Data from eight family studies of unipolar and eight family studies of bipolar probands were used to calculate family resemblance sex ratios. These observed sex ratios were then compared to sex ratios predicted by X-linked and nonfamilial effects models. Maximum likelihood estimation of competing models revealed that X linkage was not a good fit to the unipolar data. The bipolar studies were not consistent with either the X-linked or the nonfamilial effects model.

Serum neuroleptic levels, prolactin levels, and relapse: a two-year study of schizophrenic outpatients.

Abstract: For 2 years serum neuroleptic levels, prolactin levels, and clinical states were assessed in 105 male schizophrenic outpatients every 6 months. The patients were taking a variety of neuroleptics at clinically determined fixed doses. Those who had psychotic symptoms at 50% or more of their visits attained serum levels of neuroleptics and prolactin well within or above the range observed in the remitted patients. Neuroleptic and prolactin levels did not discriminate patients who relapsed from those who did not relapse. In the remitted patients who relapsed at least once during the study period, neuroleptic and prolactin serum levels were lower before the relapse episodes than before the stable periods.