S
Stephen W. Michnick
Researcher at Université de Montréal
Publications - 163
Citations - 25325
Stephen W. Michnick is an academic researcher from Université de Montréal. The author has contributed to research in topics: Protein-fragment complementation assay & Protein–protein interaction. The author has an hindex of 51, co-authored 154 publications receiving 23792 citations. Previous affiliations of Stephen W. Michnick include University of British Columbia & University of Maryland, Baltimore.
Papers
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Journal ArticleDOI
All-atom empirical potential for molecular modeling and dynamics studies of proteins.
Alexander D. MacKerell,D. Bashford,M. Bellott,Roland L. Dunbrack,Jeffrey D. Evanseck,Martin J. Field,Stefan Fischer,Jiali Gao,H. Guo,S. Ha,Diane Joseph-McCarthy,L. Kuchnir,K. Kuczera,F. T. K. Lau,C. Mattos,Stephen W. Michnick,Thien H. Ngo,D. T. Nguyen,B. Prodhom,W. E. Reiher,Benoît Roux,M. Schlenkrich,Jeremy C. Smith,Roland H. Stote,John E. Straub,Masakatsu Watanabe,J. Wiórkiewicz-Kuczera,D. Yin,Martin Karplus +28 more
TL;DR: The results demonstrate that use of ab initio structural and energetic data by themselves are not sufficient to obtain an adequate backbone representation for peptides and proteins in solution and in crystals.
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Atypical Membrane Topology and Heteromeric Function of Drosophila Odorant Receptors In Vivo
TL;DR: It is demonstrated that OR83b heterodimerizes with conventional ORs early in the endomembrane system in OSNs, couples these complexes to the conserved ciliary trafficking pathway, and is essential to maintain the OR/OR83b complex within the sensory cilia, where odor signal transduction occurs.
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An in Vivo Map of the Yeast Protein Interactome
Kirill Tarassov,Vincent Messier,Christian R. Landry,Stevo Radinovic,Mercedes M. Serna Molina,Igor Shames,Yelena Malitskaya,Jackie Vogel,Howard Bussey,Stephen W. Michnick +9 more
TL;DR: A genome-wide in vivo screen for protein-protein interactions in Saccharomyces cerevisiae by means of a protein-fragment complementation assay (PCA) identified 2770 interactions among 1124 endogenously expressed proteins, revealing a previously unexplored subspace of the yeast protein interactome.
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Erythropoietin Receptor Activation by a Ligand-Induced Conformation Change
TL;DR: An in vivo protein fragment complementation assay was used to obtain evidence for an alternative mechanism in which unliganded erythropoietin receptor dimers exist in a conformation that prevents activation of JAK2 but then undergo a ligand-induced conformation change that allows JAK1 to be activated.
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A highly sensitive protein-protein interaction assay based on Gaussia luciferase
Ingrid Remy,Stephen W. Michnick +1 more
TL;DR: A new PCA assay is described, based on the Gaussia princeps luciferase enzyme, demonstrating chemical reversal, and induction and inhibition of a key interaction linking insulin and TGFβ signaling.