S
Steve Kahn
Researcher at Amgen
Publications - 6
Citations - 5331
Steve Kahn is an academic researcher from Amgen. The author has contributed to research in topics: Amyloid precursor protein & Amyloid precursor protein secretase. The author has an hindex of 5, co-authored 6 publications receiving 5098 citations.
Papers
More filters
Journal ArticleDOI
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
Robert Vassar,Brian D. Bennett,Safura Babu-Khan,Steve Kahn,Elizabeth A. Mendiaz,Paul Denis,David B. Teplow,Sandra Ross,Patricia Amarante,Richard Loeloff,Yi Luo,Seth Fisher,Janis Fuller,Steven P. Edenson,Jackson Lile,Mark A. Jarosinski,Anja Leona Biere,Eileen Curran,Teresa L. Burgess,Jean Claude Louis,Frank H. Collins,James J. S. Treanor,Gary Rogers,Martin Citron +23 more
TL;DR: Overexpression of a transmembrane aspartic protease, termed BACE (for beta-site APP-cleaving enzyme) increased the amount of beta-secretase cleavage products, and these were cleaved exactly and only at known beta- secretase positions.
Journal ArticleDOI
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.
Yi Luo,Brad Bolon,Steve Kahn,Brian D. Bennett,Safura Babu-Khan,Paul Denis,Wei Fan,Hue Kha,Jianhua Zhang,Yunhua Gong,Laura Martin,Jean Claude Louis,Qiao Yan,William G. Richards,Martin Citron,Robert Vassar +15 more
TL;DR: These results provide validation of BACE1 as the major β-secretase in vivo and suggest that therapeutic inhibition of Bace1 for the treatment of Alzheimer's disease may be free of mechanism-based toxicity.
Journal ArticleDOI
A Furin-like Convertase Mediates Propeptide Cleavage of BACE, the Alzheimer's β-Secretase
Brian D. Bennett,Paul Denis,Mitsuru Haniu,David B. Teplow,Steve Kahn,Jean Claude Louis,Martin Citron,Robert Vassar +7 more
TL;DR: The results strongly suggest that furin, or a furin-like proprotein convertase, is responsible for cleaving the BACE propeptide domain to form the mature enzyme.
Journal ArticleDOI
Fenchylamine sulfonamide inhibitors of amyloid β peptide production by the γ-secretase proteolytic pathway : Potential small-molecule therapeutic agents for the treatment of alzheimer's disease
Gilbert M. Rishton,Daniel Martin Retz,Paul Tempest,James Novotny,Steve Kahn,James J. S. Treanor,Jack Lile,Martin Citron +7 more
Journal Article
Erratum: A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's β-secretase (The Journal of Biological Chemistry (2002) 275 (37712-37717))
Brian D. Bennett,Paul Denis,Mitsuru Haniu,David B. Teplow,Steve Kahn,Jean Claude Louis,Martin Citron,Robert Vassar +7 more
TL;DR: A Furin-like Convertase Mediates Propeptide Cleavage of BACE, the Alzheimer’s  -Secretase and the costs of publication of this article were defrayed in part by the payment of page charges.