S
Steve Kaufman
Researcher at Amgen
Publications - 13
Citations - 6730
Steve Kaufman is an academic researcher from Amgen. The author has contributed to research in topics: Osteoclast & Osteoprotegerin. The author has an hindex of 11, co-authored 13 publications receiving 6510 citations.
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Journal ArticleDOI
Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation
David L. Lacey,Emma Timms,Hong-Lin Tan,Michael J. Kelley,Colin R. Dunstan,Tim Burgess,Robin Elliott,Anne Colombero,Gary Elliott,S. Scully,Hailing Hsu,John K. Sullivan,Nessa Hawkins,E. Davy,C. Capparelli,Alana Eli,Yi-xin Qian,Steve Kaufman,Ildiko Sarosi,Victoria Shalhoub,Giorgio Senaldi,Jane Guo,John M. Delaney,William J. Boyle +23 more
TL;DR: The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGl and OPG are key extracellular regulators of osteoclast development.
Journal ArticleDOI
Osteoprotegerin Reverses Osteoporosis by Inhibiting Endosteal Osteoclasts and Prevents Vascular Calcification by Blocking a Process Resembling Osteoclastogenesis
Hosung Min,Sean Morony,Ildiko Sarosi,Colin R. Dunstan,Casey Capparelli,Sheila Scully,Gwyneth Van,Steve Kaufman,Paul J. Kostenuik,David L. Lacey,William J. Boyle,W. Scott Simonet +11 more
TL;DR: Findings indicate that the OPG/OPGL/RANK signaling pathway may play an important role in both pathological and physiological calcification processes and may also explain the observed high clinical incidence of vascular calcification in the osteoporotic patient population.
Journal ArticleDOI
Pegylated Megakaryocyte Growth and Development Factor Abrogates the Lethal Thrombocytopenia Associated With Carboplatin and Irradiation in Mice
Martha M. Hokom,David L. Lacey,Olaf B Kinstler,Esther S. Choi,Steve Kaufman,Judy Faust,Christopher G. Rowan,Erik Dwyer,Janet L. Nichol,Timothy Grasel,John Wilson,Randy Steinbrink,Randy Ira Hecht,Dwight Winters,Thomas C. Boone,Pamela Hunt +15 more
TL;DR: The concept that PEG-rMGDF may be useful to treat iatrogenic thrombocytopenias is supported, as the daily administration of pegylated recombinant human MGDF significantly reduced mortality and ameliorated the depth and duration of thromBocy topenia.
Journal ArticleDOI
Osteoprotegerin and osteoprotegerin ligand effects on osteoclast formation from human peripheral blood mononuclear cell precursors.
Victoria Shalhoub,Judy Faust,William J. Boyle,Colin R. Dunstan,Michael J. Kelley,Steve Kaufman,Sheila Scully,Gwyneth Van,David L. Lacey +8 more
TL;DR: A pivotal role for OPGL and OPG in the modulation of human osteoclast differentiation and function is confirmed, suggesting a use for O PG for treating osteocline‐mediated bone disease in humans.
Journal ArticleDOI
Characterization of osteoclast precursors in human blood.
Victoria Shalhoub,Gary Elliott,L. Chiu,R. Manoukian,Michael J. Kelley,Nessa Hawkins,E. Davy,Grant Shimamoto,J. Beck,Steve Kaufman,Gwyneth Van,S. Scully,Meiying Qi,Mario Grisanti,Colin R. Dunstan,William J. Boyle,David L. Lacey +16 more
TL;DR: All freshly isolated monocytes demonstrate displaceable Hu-OPGL-F binding, suggesting the presence of RANK on OCPs in PB; also, OCPS within a purified PB monocyte population form osteoclast-like cells in the complete absence of other cell types in OPGL and CSF-1 containing medium.