Steve Vucic

TL;DR: This paper summarized current concepts about the origin of the disease, what predisposes patients to develop the disorder, and discuss why all cases of ALS are not the same, focusing on the small steps of extending longevity, improving therapies, undertaking clinical trials, and compiling population registries to the overarching goals of establishing the measures that guard against onset and finding the triggers for this neurodegenerative disorder.

TL;DR: This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.

TL;DR: Identification of C9orf72 repeat expansions in patients without a family history of ALS challenges the traditional division between familial and sporadic disease.

TL;DR: Simultaneous investigation of central and peripheral excitability has established that cortical hyperexcitability develops in clinically affected SOD-1 FALS patients, similar to that seen in sporadic ALS patients, thereby suggesting that a similar pathophysiological process in evident in both familial and sporadic ALS Patients.

TL;DR: Relapsing MOG antibody-associated demyelination is strongly associated with ON across all age groups and ADEM in children, and patients are highly responsive to steroids, but vulnerable to relapse on steroid reduction and cessation.